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Muscle Blood Flow Regulation in HFpEF

VA Office of Research and Development · NCT05115890

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
35
US sites recruiting
1
Study start
July 1, 2022
Record last updated
April 21, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Heart failure with preserved ejection (HFpEF) disproportionately affects Veterans and is the number one reason for hospital discharge in the VA Health Care System. Exercise intolerance is a common complication experienced by patients with HFpEF, perpetuating physical inactivity and accelerating disease progression. This research proposal aims to elucidate mechanisms responsible for inadequate skeletal muscle blood flow and exercise intolerance in patients with HFpEF compared with healthy controls as well as following 8 weeks of exercise training in patients with HFpEF only.

Being studied: Exercise training

Conditions: HFpEF

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age 18 years or older and able to give written informed consent
  • New York Heart Association (NYHA) functional class II or III
  • Left Ventricular Ejection Fraction (LVEF) > 50%
  • Plasma Brain Natriuretic Peptide (BNP) >200 pg/mL or NT-proBNP 400 pg/mL at enrollment

Exclusion Criteria

  • Prior EF of \<50%.
  • NYHA Class IV or HF that cannot be stabilized on optimized pharmacotherapy
  • Acute coronary syndrome, infiltrative cardiomyopathy, or myocarditis
  • Patients with HFpEF secondary to significant uncorrected primary valvular disease (except mitral regurgitation secondary to left ventricular dysfunction)
  • Orthopedic limitations that would prohibit knee-extensor exercise
  • Women currently taking hormone replacement therapy (HRT) will be excluded from the proposed studies due to the direct vascular effects of HRT
  • Women who are pregnant or may become pregnant, but the typical age of female patients with HFpEF will be postmenopausal
  • Current smokers

Recruiting US locations

  • VA Salt Lake City Health Care System, Salt Lake City, UT

    Salt Lake City, UT 84148-0001

    Site contact: Kanokwan Bunsawat, PhD · 801-582-1565 · Kanokwan.Bunsawat@va.gov

Study contacts (from the official record)

  • Kanokwan Bunsawat, PhD · (801) 582-1565 · Kanokwan.Bunsawat@va.gov
  • David W Wray, PhD · (801) 582-1565 · David.Wray2@va.gov
All healthy volunteers studies in Utah →
Muscle Blood Flow Regulation in HFpEF (NCT05115890) | Bored Studies