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Near-Infrared Spectroscopy, Acute Taurine Supplementation, and Isolated Muscular Endurance and Fatigue Resistance in Young Healthy Adults

Louisiana State University and A&M College · NCT07654946

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Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–40 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
34
US sites recruiting
1
Study start
July 15, 2026
Record last updated
August 26, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to determine the association between near-infrared spectroscopy (NIRS)-derived mitochondrial oxidative phosphorylation (OXPHOS) capacity of the vastus lateralis muscles, and both local muscular endurance capacity and local muscular fatigability of the thigh muscles in young adults. Additionally, this trial aims to determine the effect of acute taurine supplementation on local muscular endurance capacity and local muscular fatigability when compared to a placebo condition. The main questions it aims to answer are:

  • Will there be a positive correlation between NIRS rate constant (a marker of mitochondrial function) and local muscular endurance capacity, along with a negative correlation between NIRS rate constant and local muscular fatigability?
  • Will acute taurine supplementation lead to improvements in local muscular endurance capacity and local muscular fatigability when compared to a placebo condition?

Participants will

  • Complete a NIRS assessment to non-invasively assess the mitochondrial capacity of both vastus lateralis muscles
  • Complete two acute supplementation assessment visits (separated by 7-10 days) which involve small blood collections before and after taurine or placebo supplementation
  • Perform a single-leg extension time-to-exhaustion test to measure local muscular endurance capacity on one leg, along with a repeated maximal voluntary isometric contraction fatigue index test to measure local muscular fatigability on the opposite leg, during each acute supplementation assessment visit.

Being studied: Acute Taurine Supplementation; Acute Placebo Supplementation

Conditions: Local Muscular Endurance and Fatigue; NIRS Skeletal Muscle Mitochondrial Capacity; Acute Taurine Supplementation

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Capable and willing to give written informed consent
  • Capable of understanding inclusion and exclusion criteria
  • No medical condition that would limit participation in supervised exercise
  • No current prescription medications known to impact mitochondrial function
  • Sedentary or recreationally active (self-report average MVPA \< 300 mins/week)
  • Willing to allow researchers to use data for research purposes

Exclusion Criteria

  • Self-report history of diabetes mellitus
  • Self-report history of cardiovascular, peripheral vascular, cerebral vascular, pulmonary, or renal disease
  • Self-report history of uncontrolled hypertension (resting systolic blood pressure > 180 mmHg or diastolic blood pressure > 100 mmHg)
  • Self-report history of blood clotting disorders
  • Self-report history of sickle cell trait
  • Self-report history of myopathy leading to muscle loss, weakness, severe cramps, or myalgia
  • Self-report history of musculoskeletal disorders
  • Self-report history of lower limb musculoskeletal injuries that may cause significant differences in the functional capacities of the right and left legs
  • Self-report history of neurological disorders
  • Active tobacco, E-cigarette, or nicotine use
  • Recent (within previous 2 weeks) consumption of energy drinks or supplements containing ≥ 1 gram of taurine on > 2 days/week
  • Actively taking medications to treat blood-clotting disorders
  • Any condition that, in the judgement of the Principal Investigator, may interfere with study participation and adherence to the protocol
  • Participants may be excluded if measured adipose tissue thickness is > 2.0 cm at the site of NIRS assessment or if the accessor is unable to obtain high-quality NIRS signals

Recruiting US locations

  • Huey P. Long Fieldhouse Exercise Physiology Laboratory

    Baton Rouge, LA 70802

    Site contact: Efthymios Papadopoulos, PhD · 225-578-0938 · epap@lsu.edu

Study contacts (from the official record)

  • Efthymios Papadopoulos, PhD · 225-578-0938 · epap@lsu.edu
  • Carlante Emerson, MS · 225-733-4693 · cemers2@lsu.edu
Near-Infrared Spectroscopy, Acute Taurine Supplementation, and… (NCT07654946) | Bored Studies