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Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2

Hugo W. Moser Research Institute at Kennedy Krieger, Inc. · with National Institute of Neurological Disorders and Stroke (NINDS) · NCT07278388

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–75 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
200
US sites recruiting
1
Study start
July 16, 2025
Record last updated
December 12, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This proposal aims to understand the neurobiological mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). This knowledge will eventually provide candidate mechanisms to target with pharmacological intervention and inform rehabilitative care for those individuals suffering from symptoms of fatigue in PASC.

Being studied: Physical Fatigue

Conditions: PASC Post Acute Sequelae of COVID 19; Fatigue

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age 18 to 75 years old.
  • Have received a clinical diagnosis of post-acute sequelae of SARS-CoV-2 (PASC)/long COVID syndrome using the criteria specified by Thaweethai, et al., 2023 (JAMA). This symptom checklist provides a score based on the number and severity of symptoms. An individual with a score >12 is classified as having PASC.
  • Currently experiencing Fatigue/Brain Fog as assessed with the Post-COVID symptom checklist and the PedsQL questionnaire.

Exclusion Criteria

  • Neurological disorders including, but not limited to, stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease, or any other neuromuscular disease (self-report).
  • Diagnosed history of severe psychiatric diseases such as depression and schizophrenia (self-report).
  • Congestive heart failure.
  • Peripheral artery disease with claudication.
  • Cancer.
  • Pulmonary or renal failure.
  • Unstable angina.
  • Uncontrolled hypertension (more than 190/110 mmHg).
  • Severe aphasia.
  • Orthopedic or pain conditions.
  • Have had exposure to metal or metal implants, due to the hazardous effects of the magnetic field.
  • If on immunomodulatory therapy, they must have been on that therapy for at least 6 months before the start of the study.

Healthy age- and sex-matched controls for PASC - Exclusion criteria: Participants with a history of any of the following will be excluded from the study:

  • Hospitalization due to SARS-CoV-2 infection.
  • Neurological disorders including, but not limited to, stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease, or any other neuromuscular disease (self-report).
  • Diagnosed history of severe psychiatric diseases such as depression and schizophrenia (self-report).
  • Congestive heart failure.
  • Peripheral artery disease with claudication.

Recruiting US locations

  • Kennedy Krieger Institute

    Baltimore, MD 21201

    Site contact: Anthony Gonzalez · 443-923-2716 · gonzalezan@kennedykrieger.org

Study contacts (from the official record)

  • Anthony Gonzalez · 443-923-2716 · gonzalezan@kennedykrieger.org
  • Vikram Chib, PhD
All healthy volunteers studies in Maryland →
Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2 (NCT07278388) | Bored Studies