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Neural Mechanisms of Interpersonal Expectations on Negative Affect

Trustees of Dartmouth College · NCT06980090

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–55 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
196
US sites recruiting
1
Study start
September 1, 2025
Record last updated
June 11, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence these effects.

The main questions this study aims to answer are: (1)Does active tTIS reduce negative affect more effectively than sham (inactive) tTIS? (2)Do positive treatment expectations enhance the effects compared to negative expectations?

Participants will: (1) Receive either active or sham tTIS. (2) Be provided with positive or negative messaging regarding treatment effectiveness. (3) Interact with care providers and complete assessments measuring negative affect and physiological responses.

Being studied: Session A: Positive Placebo + Active tTIS; Session B: Positive Placebo + Sham tTIS; Session C: Negative Placebo + Active tTIS; Session D: Negative Placebo + Sham tTIS; Session E: On-Placebo + Sham tTIS; Session F: Off-Placebo + Sham tTIS

Conditions: Negative Affectivity; Non-invasive Brain Stimulation; Placebo Effect; Expectations

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

'Doctors' are recruited from medical students at the Geisel School of Medicine and resident physicians at Dartmouth Hitchcock Medical Center (DHMC).

Exclusion Criteria

  • No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis
  • No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis that can cause cognitive impairment
  • No self-reported current chronic pain, or acute pain within three months of the study period
  • No current migraine disorder (i.e., 15 headache days or more in 1 month)
  • No use of central nervous system-effective medication or other medication for neurological/psychiatric treatment
  • No self-reported substance abuse within the last six months
  • No contraindication to MRI or tTIS (e.g., pregnancy, claustrophobia, pacemakers, ear/cochlear implants, shrapnel injuries, clips, or other ferromagnetic/electrical objects/devices, diagnosed brain abnormality such as tumor, or skin lesions on the scalp.)
  • No contraindications for induced pain (e.g., no heart disease, high blood pressure, heart surgery, heart problems of any kind, severe asthma, respiratory problems of any kind, fibromyalgia, Raynaud's Syndrome or Disease, chronic pain, diabetes)
  • Participants must be capable of performing experimental tasks (e.g., are able to read), are fluent or native speakers of English
  • Participants must be able to tolerate the maximum level of thermal pain stimuli (for thermal stimuli)

Recruiting US locations

  • Dartmouth College, Department of Psychological and Brain Sciences

    Hanover, NH 03755

    Site contact: Tor D. Wager, Ph.D. · 603-646-2196 · tor.d.wager@dartmouth.edu

Study contacts (from the official record)

  • Zhaoxing Wei, Ph.D. · 6033220577 · zhaoxing.wei@dartmouth.edu
Neural Mechanisms of Interpersonal Expectations on Negative Affect (NCT06980090) | Bored Studies