Neural Mechanisms of Interpersonal Expectations on Negative Affect
Trustees of Dartmouth College · NCT06980090
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 18–55 · All sexes
- Healthy volunteers
- Accepted
- Study type
- Interventional · Not applicable
- Target enrollment
- 196
- US sites recruiting
- 1
- Study start
- September 1, 2025
- Record last updated
- June 11, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence these effects.
The main questions this study aims to answer are: (1)Does active tTIS reduce negative affect more effectively than sham (inactive) tTIS? (2)Do positive treatment expectations enhance the effects compared to negative expectations?
Participants will: (1) Receive either active or sham tTIS. (2) Be provided with positive or negative messaging regarding treatment effectiveness. (3) Interact with care providers and complete assessments measuring negative affect and physiological responses.
Being studied: Session A: Positive Placebo + Active tTIS; Session B: Positive Placebo + Sham tTIS; Session C: Negative Placebo + Active tTIS; Session D: Negative Placebo + Sham tTIS; Session E: On-Placebo + Sham tTIS; Session F: Off-Placebo + Sham tTIS
Conditions: Negative Affectivity; Non-invasive Brain Stimulation; Placebo Effect; Expectations
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
Inclusion Criteria
'Doctors' are recruited from medical students at the Geisel School of Medicine and resident physicians at Dartmouth Hitchcock Medical Center (DHMC).
Exclusion Criteria
- No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis
- No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis that can cause cognitive impairment
- No self-reported current chronic pain, or acute pain within three months of the study period
- No current migraine disorder (i.e., 15 headache days or more in 1 month)
- No use of central nervous system-effective medication or other medication for neurological/psychiatric treatment
- No self-reported substance abuse within the last six months
- No contraindication to MRI or tTIS (e.g., pregnancy, claustrophobia, pacemakers, ear/cochlear implants, shrapnel injuries, clips, or other ferromagnetic/electrical objects/devices, diagnosed brain abnormality such as tumor, or skin lesions on the scalp.)
- No contraindications for induced pain (e.g., no heart disease, high blood pressure, heart surgery, heart problems of any kind, severe asthma, respiratory problems of any kind, fibromyalgia, Raynaud's Syndrome or Disease, chronic pain, diabetes)
- Participants must be capable of performing experimental tasks (e.g., are able to read), are fluent or native speakers of English
- Participants must be able to tolerate the maximum level of thermal pain stimuli (for thermal stimuli)
Recruiting US locations
Dartmouth College, Department of Psychological and Brain Sciences
Hanover, NH 03755
Site contact: Tor D. Wager, Ph.D. · 603-646-2196 · tor.d.wager@dartmouth.edu
Study contacts (from the official record)
- Zhaoxing Wei, Ph.D. · 6033220577 · zhaoxing.wei@dartmouth.edu
Similar studies in New Hampshire
All healthy volunteers studies in New Hampshire →- RecruitingHealthy volunteers
Observational Study of Decentralized Urine Optical Interaction Patterns Associated With Environmental Microplastic and Nanoplastic Exposure
Ecotera Health LLC
- Location
- Manchester, NH + 50 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Cogito: A Turnkey Solution for Rapidly Developing, Evaluating, Deploying, and Scaling Digital Therapeutics
Square2 Systems, Inc.
- Location
- Hanover, NH
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 2
Study of Cross-Cutting E-Health Prevention Approaches
University of New Hampshire
- Location
- Durham, NH
- Eligibility basics
- Ages 18–24
- RecruitingHealthy volunteers
Genetic Risk, Parental Feeding Practices, and Appetitive Traits in Early Life
Trustees of Dartmouth College
- Location
- Hanover, NH
- Eligibility basics
- Ages 2–6