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Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model

University of Michigan · with National Institute on Drug Abuse (NIDA) · NCT07094061

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–22 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
294
US sites recruiting
1
Study start
October 3, 2025
Record last updated
June 10, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study seeks to understand individual differences in personality, brain function, and behavior.

Study hypothesis

  • A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.

Being studied: fMRI; Questionnaires and surveys; Behavioral tasks and eye tracking

Conditions: Substance Use; Healthy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 18-22 years old at baseline
  • Right-handed
  • Medically/physically able to give informed consent
  • English-speaking
  • Substance use is free to vary, but for participants with a history of substance use, ≥ 1 use of cannabis (including less than a full dose)

Exclusion Criteria

  • Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine)
  • History of psychosis in self or first-degree relative
  • Current treatment for substance use disorder
  • Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication)
  • Intelligence quotient (IQ) \< 70
  • Lifetime history of head trauma with loss of consciousness > 5 minutes
  • Reliance on glasses to be able to read small text at a distance of approximately 30 inches
  • Colorblindness
  • MRI contraindication (e.g., pregnancy, metal implants, claustrophobia) per protocol

Recruiting US locations

  • Rachel Upjohn Building

    Ann Arbor, MI 48109

    Site contact: Loree Brennan O'Jack, CPA, MHSA · 734-232-0227 · loree@med.umich.edu

Study contacts (from the official record)

  • Paul Holdefer, MPH · 734-998-9239 · holdefer@umich.edu
All healthy volunteers studies in Michigan →
Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging… (NCT07094061) | Bored Studies