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Neuroimaging of Parkinson's

Washington University School of Medicine · with National Institute of Neurological Disorders and Stroke (NINDS), Michael J. Fox Foundation for Parkinson's Research · NCT07024875

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 40+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
120
US sites recruiting
1
Study start
August 1, 2025
Record last updated
April 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network (SCAN), which could be a primary locus of dysfunction in PD. Here, the investigators will use magnetic resonance imaging techniques in PD patients to test whether SCAN is critical for PD. The investigators will determine whether SCAN is connected to PD-relevant subcortical structures, and whether PD patients exhibit altered subcortical-to-SCAN connectivity. If successful, this work will identify SCAN as a specific circuit altered in PD patients that can serve as a new target for future neuromodulatory PD therapies.

Conditions: Parkinsons Disease (PD)

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Must meet specific health and cognitive criteria depending on the group. For PD participants
  • Clinical diagnosis of Parkinson's Disease
  • Must not meet dementia criteria For Healthy Control Participants
  • Normal or benign neurological exam
  • Normal cognition
  • No first-degree relatives with Parkinson's Disease

Exclusion Criteria

  • Neurological Disorders (other than PD)
  • Any other neurological condition
  • Significant Head Injury
  • Head injury with loss of consciousness >5 minutes
  • Or any neurological sequelae
  • Psychiatric Disorders
  • Schizophrenia
  • Bipolar Disorder
  • Epilepsy
  • Serious Medical Conditions
  • End-stage organ failure
  • Ongoing cancer treatment
  • Cognitive Impairment
  • Diagnosis of dementia
  • MMSE score \<24 or MoCA score \<21
  • MRI contraindications
  • Metal implants
  • claustrophobia
  • Weight over 300 lbs (due to weight restrictions of the MRI scanner)

Recruiting US locations

Study contacts (from the official record)

  • Danny Bower · 314-273-4429 · bower@wustl.edu
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Neuroimaging of Parkinson's (NCT07024875) | Bored Studies