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Neurostimulation for the Treatment of Post-Stroke Aphasia

QVITI S.A. · with Icahn School of Medicine at Mount Sinai · NCT05194566

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–80 · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Not applicable
Target enrollment
64
US sites recruiting
2
Study start
September 6, 2023
Record last updated
February 18, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.

Being studied: tACS

Conditions: Post-stroke Aphasia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Individuals with aphasia (assessed using the Boston Diagnostic Aphasia Examination) who perform the Naming Task in the range of 10%-60% accuracy will be included in the study. The overall baseline score in the Naming Task will be estimated from the two baseline measurements.

Inclusion Criteria

  • diagnosis of aphasia: Broca's or mixed (based on the assessment of a Speech Language Pathologist).
  • presence of a focus of injury in the left hemisphere (within one hemisphere only) as a result of the first ischemic or hemorrhagic stroke (based on CT/MRI examination);
  • chronic stage of the disease - time since the stroke occurred over 6 months.
  • ability to achieve an accuracy in the Naming Task of 10-60%.
  • 18-80 years
  • right-handedness before the stroke.
  • ability to give informed written consent.
  • fluency in English.

Exclusion Criteria

  • severe cognitive, auditory or visual impairment that would preclude cognitive and language testing - inability to follow a two-step command.
  • presence of metal implants in the skull.
  • presence of major untreated or unstable psychiatric disease.
  • history of epilepsy or seizures.
  • ongoing medication that increases the risk of epileptic seizures.
  • presence in the body of cardiac stimulator, pacemaker or vagus nerve stimulator (implanted).
  • history of speech, language, hearing, or intellectual disability during childhood.
  • pregnancy (based on declarations)

Exclusion criteria during the trial

  • high intolerance to stimulation.
  • occurrence of an epileptic seizure.
  • other previously absent neurological or mental symptoms

Withdrawal criteria

  • high intolerance to stimulation (participants experience severe discomfort during stimulation);
  • occurrence of an epileptic seizure;
  • other previously absent neurological, physical or mental symptoms.

Recruiting US locations

  • Think & Speak Lab at Shirley Ryan AbilityLab

    Chicago, IL 60611

    Site contact: Tertia Jeppson, M.A., CCC-SLP, CBIS · 312-238-6163 · tjeppson@sralab.org

  • Abilities Research Center at Mount Sinai

    New York, NY 10029

    Site contact: Raphael Kesselman · 917-886-4668 · raphael.kesselman@mountsinai.org

Study contacts (from the official record)

  • Tertia Jeppson · 312-238-6163 · tjeppson@sralab.org
  • Aidan Rogers · (718) 308-9450 · aidan.rogers@mountsinai.org
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Neurostimulation for the Treatment of Post-Stroke Aphasia (NCT05194566) | Bored Studies