Neurostimulation for the Treatment of Post-Stroke Aphasia
QVITI S.A. · with Icahn School of Medicine at Mount Sinai · NCT05194566
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 18–80 · All sexes
- Healthy volunteers
- Not accepted (a condition is required)
- Study type
- Interventional · Not applicable
- Target enrollment
- 64
- US sites recruiting
- 2
- Study start
- September 6, 2023
- Record last updated
- February 18, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.
Being studied: tACS
Conditions: Post-stroke Aphasia
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
Individuals with aphasia (assessed using the Boston Diagnostic Aphasia Examination) who perform the Naming Task in the range of 10%-60% accuracy will be included in the study. The overall baseline score in the Naming Task will be estimated from the two baseline measurements.
Inclusion Criteria
- diagnosis of aphasia: Broca's or mixed (based on the assessment of a Speech Language Pathologist).
- presence of a focus of injury in the left hemisphere (within one hemisphere only) as a result of the first ischemic or hemorrhagic stroke (based on CT/MRI examination);
- chronic stage of the disease - time since the stroke occurred over 6 months.
- ability to achieve an accuracy in the Naming Task of 10-60%.
- 18-80 years
- right-handedness before the stroke.
- ability to give informed written consent.
- fluency in English.
Exclusion Criteria
- severe cognitive, auditory or visual impairment that would preclude cognitive and language testing - inability to follow a two-step command.
- presence of metal implants in the skull.
- presence of major untreated or unstable psychiatric disease.
- history of epilepsy or seizures.
- ongoing medication that increases the risk of epileptic seizures.
- presence in the body of cardiac stimulator, pacemaker or vagus nerve stimulator (implanted).
- history of speech, language, hearing, or intellectual disability during childhood.
- pregnancy (based on declarations)
Exclusion criteria during the trial
- high intolerance to stimulation.
- occurrence of an epileptic seizure.
- other previously absent neurological or mental symptoms
Withdrawal criteria
- high intolerance to stimulation (participants experience severe discomfort during stimulation);
- occurrence of an epileptic seizure;
- other previously absent neurological, physical or mental symptoms.
Recruiting US locations
Think & Speak Lab at Shirley Ryan AbilityLab
Chicago, IL 60611
Site contact: Tertia Jeppson, M.A., CCC-SLP, CBIS · 312-238-6163 · tjeppson@sralab.org
Abilities Research Center at Mount Sinai
New York, NY 10029
Site contact: Raphael Kesselman · 917-886-4668 · raphael.kesselman@mountsinai.org
Study contacts (from the official record)
- Tertia Jeppson · 312-238-6163 · tjeppson@sralab.org
- Aidan Rogers · (718) 308-9450 · aidan.rogers@mountsinai.org
Similar studies in Illinois
All neurology studies in Illinois →- RecruitingHealthy volunteersEarly Phase 1
Effect of Neural Constraints on Movement in Stroke
Northwestern University
- Location
- Chicago, IL
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersEarly Phase 1
R01.Aim 2.Study 1: IsoReach
Shirley Ryan AbilityLab
- Location
- Chicago, IL
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Development of a Home Test for Measuring Blood P-tau217 in Alzheimer's Disease Using the Tasso Lancet Device
Neurogen Biomarking LLC
- Location
- Chicago, IL
- Eligibility basics
- Ages 40–90
- RecruitingHealthy volunteers
Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment…
GAP Innovations, PBC
- Location
- Chicago, IL + 18 other US sites
- Eligibility basics
- Ages 60–90