RecruitingAccepts healthy volunteersEarly Phase 1

New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)

University of Utah · with National Heart, Lung, and Blood Institute (NHLBI) · NCT04600115

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

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This study's main specific aims are;

To develop robust acquisition and reconstruction methods specifically for the study of microvascular cardiac remodeling with MRI which will include very innovative quantitative perfusion methods, as well as fibrosis quantification, longitudinal strain, and phase contrast imaging for flow.
Test the new methods for identifying the clinical task of characterizing HFpEF.

Being studied: Adenosine; Regadenoson; O-15 labeled radioactive water; MRI; PET Imaging

Conditions: MRI Scans

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Group A (volunteers, with or without cardiac disease): Volunteers will be available for at least one study visit
Group B (HFpEF patient volunteers): Volunteers will have a diagnosis of HFpEF and be safe to be imaged with MRI

Exclusion Criteria

minors
Critically ill patients, patients on ventilators, patients with unstable angina or with hypotension, asthmatics, and other patients whose medical care or safety may be at risk from undergoing an MRI examination will be excluded.
Patients with claustrophobia will also be excluded from the study if this cannot be controlled with standard methods (valium or benadryl).
Patients with contraindication to MRI (metal implants, or certain types of heart valves),
pregnant patients, , mentally disabled patients and prisoners will be excluded from this study. (All criteria apply to patients and normal volunteers).
Gadolinium nephrotoxicity will be addressed by having patients with abnormal kidney function (GFR\<30) excluded from the study due to the (very small) risk associated with gadolinium contrast agents.
This threshold may be modified, depending on practices determined by the Radiology Department and the IRB.
Patients with a known allergy or contraindication to Adenosine and/or Regadenoson will be excluded from stress MRI cohorts.
All participants that will receive a stress agent will refrain from consuming caffeine for at least 12 hours prior to each MRI
Subjects with a known contraindication to Adenosine and/or Regadenoson will only be enrolled in scans where no stress agent will be administered

university of Utah, Radiology Research
Salt Lake City, UT 84108
Site contact: Olivia Pratt, BS · 801-585-6142 · u0447662@umail.utah.edu