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New Non-invasive Modalities for Assessing Retinal Structure and Function

Randy Kardon · NCT03475173

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–99 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
500
US sites recruiting
1
Study start
May 6, 2019
Record last updated
September 8, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study investigates a new technology to assess the structure and function inside the eye. Retinal imaging of subjects with inner and outer retinal defects to detect areas of abnormal structure and function compared to other visual function tests.

Being studied: LSFG-NAVI

Conditions: Ischemic Optic Neuropathy; Branch Retinal Artery Occlusion; Hemianopia; Leber Hereditary Optic Neuropathy; Acute Zonal Occult Outer Retinopathy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Controls

Inclusion

Normal eye exam in last 2 years

Exclusion

Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. Any abnormalities of the retina or optic nerve that could affect metabolism of the retina outside of normal.

Subjects with Inner Retina Defect

Inclusion

Defined structural defect to include those with Ischemic optic neuropathy, branch retinal artery occlusion (BRAO), hemianopia or visual field defect that respects the vertical meridian, inherited mitochondrial optic neuropathies such as Leber's and Dominant Optic Neuropathy, other retinopathies or optic neuropathies.

Exclusion

Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.

Subjects with Outer Retinal Defect

Inclusion

AZOOR (acute zonal occult outer retinopathy) or other focal or diffuse outer photoreceptor loss of function

Exclusion

Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.

The 450 total is to allow for exclusion of some subjects or in the event that the enrolled subject blinks too much or cannot fixate on a visual target adequately to maintain the same eye position during the short imaging interval. We hope to have a total of 450 (50 controls and 400 patients)

Recruiting US locations

  • University of Iowa Department of Ophthalmology

    Iowa City, IA 52242

    Site contact: Denise L Rettig, MHA. MBA · 319-356-2866 · denise-rettig@uiowa.edu

Study contacts (from the official record)

  • Julie K Nellis, BSN · 319-356-8299 · julie-nellis@uiowa.edu
  • Jan M Full, BSN · 319-356-8299 · jan-full@uiowa.edu
All neurology studies in Iowa →
New Non-invasive Modalities for Assessing Retinal Structure and… (NCT03475173) | Bored Studies