Skip to content
Bored Studies
RecruitingAccepts healthy volunteers

Night Owl Metabolism

Johns Hopkins University · with Lawson Wilkins Pediatric Endocrine Society, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NCT06507722

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–23 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
70
US sites recruiting
1
Study start
February 25, 2025
Record last updated
May 11, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The proposed study uses a novel and rigorous randomized cross-over study design in youth (18-23y) with late and non-late chronotype (n=35 per group) to assess the glycemic effect of "aligning" an oral glucose tolerance test (OGTT) or first-meal of day to a subject's chronotype. Both groups will undergo 2 OGTTs (aligned and mis-aligned with chronotype) to compare glucose tolerance and insulin sensitivity within-subject (primary outcome) and between groups (Aim 1). Then, youth will also undergo two standardized meals (aligned and mis-aligned with chronotype) while wearing continuous glucose monitoring to compare post-prandial glucose excursions within-subject and between groups (Aim 2). A pilot Exploratory Aim 3 (n=12 per group) will investigate delayed melatonin patterns under dim-light as a potential pathophysiologic mechanism behind abnormal glucose tolerance in youth with late chronotype on morning OGTTs.

Being studied: Timing of OGTT; Timing of Standardized Meal

Conditions: PreDiabetes; Overweight; Impaired Glucose Tolerance

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Overweight similar to (BMI ≥ 85th percentile but \<95th percentile for age and sex per Centers for Disease Control and Prevention growth curves (as Centers for Disease Control and Prevention growth curves contain ages ≤ 20y; if ages 21-23 years, the BMI ≥ 85th and \<95th percentile equivalents for a 20-year-old will be used))
  • Post-pubertal
  • Normal sleep duration (avg. >7 hours of sleep per night)
  • Social jetlag (difference between weekend and weekday sleep) of \< 2 hours.

Exclusion Criteria

  • Known diabetes, sleep disorders, major organ system illness, pregnancy, or genetic syndrome
  • Medication use known to affect insulin sensitivity, glucose tolerance, or circadian rhythm
  • Screening high risk for obstructive sleep apnea
  • Night shift work.

Recruiting US locations

  • Johns Hopkins School of Medicine

    Baltimore, MD 21287

    Site contact: Talia Hitt, MD/MPH/MSHP · 860-324-0072 · thitt2@jhmi.edu

Study contacts (from the official record)

  • Talia Hitt, MD/MPH/MSHP · 860-324-0072 · thitt2@jhmi.edu
All weight loss studies in Maryland →
Night Owl Metabolism (NCT06507722) | Bored Studies