Non-Ablative Laser to Treat Scarring Alopecia With Hair Follicle Gene Expression Analysis

Inclusion Criteria

• Healthy males and females, at least 18 years of age at time of informed consent, seeking treatment for scarring alopecia
• Subject must be able to read, understand, and voluntarily sign and date an IRB-approved informed consent form
• Subjects with biopsy-proven or clinically diagnosed scarring alopecia recorded within the past 6 months. An established clinical diagnosis will be confirmed by a licensed dermatologist as in previously published hair plucking studies (eg. using trichoscopy and a positive pull test). Subjects must have a stable hair loss treatment regimen with a plateau in results for at least 3 months.
• Subject agrees to not make any changes to their daily hair treatment regimen or start any medications for hair loss such as minoxidil during the study.
• Subjects able and willing to comply with the treatment protocol and follow-up schedule and requirements.
• Understands and accepts the obligation not to undergo any other procedures in the areas to be treated throughout the follow-up period.

Exclusion Criteria

• Subject does not have capacity to consent to the study
• No ethnic or racial group restrictions
• Subject does not have scarring alopecia
• History of intralesional steroid injections to the scalp in the last 12 months
• Pregnant Women
• Any medical condition that in the consideration of the investigator, would present an increased risk of a photosensitivity reaction to the subject.
• Any previous hospitalization or surgical procedure in the treatment area in the past 12 months, or major surgery in the last 6 months.
• Allergy or history of prior reaction to lidocaine
• History of immunosuppression/immune deficiency disorders (including AIDS and HIV infection), and/or any history of systemic chemotherapy in the prior 12 months.
• Recent COVID-19 infection
• History or current use of the following prescription medications:
• Immunosuppressive medications/biologics, 6 months prior to and during the study
• Accutane or other systemic retinoids within the past twelve months
• Smoking or vaping in the past 12 months.
• History of uncontrolled hyperlipidemia, uncontrolled diabetes mellitus, uncontrolled hepatitis, or uncontrolled bleeding disorders.
• History of major depressive disorders or uncontrolled endocrine disorders including but not limited to; hypothyroidism, Hashimoto's thyroiditis, or hyperthyroidism.