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Noninvasive Brain Stimulation in Adult Amblyopia

Midwestern University · NCT06712849

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Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–55 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
60
US sites recruiting
1
Study start
May 1, 2024
Record last updated
December 12, 2024

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this randomized controlled trial is to investigate the effectiveness of non-invasive brain stimulation in treating adults with amblyopia. The main questions it aims to answer are:

  • What are the effects of non-invasive brain stimulation on neuronal plasticity in the visual cortex of adults with amblyopia, and does it produce lasting changes?
  • Do cumulative sessions of non-invasive brain stimulation influence neural plasticity and higher-order visual functions in adults with amblyopia?

The investigators hypothesize that non-invasive brain stimulation will show a positive cumulative effect after five (5) consecutive days of stimulation on visual perception and function in adults with amblyopia.

Participants will be randomized into one of two treatment groups:

  • High-frequency transcranial random noise stimulation (hf-tRNS).
  • Sham stimulation.

Researchers will compare baseline measurements of crowded visual acuity, contrast sensitivity, stereoacuity, phosphene thresholds, global motion perception, form pattern recognition and pattern-reversal visual evoked potentials (VEPs) to post-treatment measurements for each group.

Being studied: Sham Transcranial Random Noise Stimulation; High Frequency Transcranial Random Noise Stimulation

Conditions: Amblyopia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adults between 18 and 55 years of age
  • Formal diagnosis of amblyopia in one or both eyes of any etiology

Exclusion Criteria

  • History of optic nerve disease, including glaucoma and optic neuritis
  • History of neurological conditions, including demyelinating disease or stroke
  • Presence of metal or electronic implants in or on the body, including pacemakers
  • Taking medications that can affect normal neurological function, including antipsychotics, antiepileptics, and opioids

Recruiting US locations

  • Midwestern University Eye Institute

    Downers Grove, IL 60515

    Site contact: Sherri Olsen · 630-515-7368 · solsen@midwestern.edu

Study contacts (from the official record)

  • Arijit Chakraborty, PhD · 630-960-3172 · achakr@midwestern.edu
  • Adrienne C Quan, OD · 630-960-3183 · aquan@midwestern.edu
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Noninvasive Brain Stimulation in Adult Amblyopia (NCT06712849) | Bored Studies