Skip to content
Bored Studies
RecruitingAccepts healthy volunteers

Objectively Diagnose and Monitor Treatment of Light Sensitivity

Randy Kardon · NCT03694626

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–80 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
120
US sites recruiting
1
Study start
July 11, 2019
Record last updated
September 8, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and autonomic nerve responses to light.

Being studied: Pupillography; Ocular Coherence Tomography (OCT); Wrist-watch sensor device; Videography; Electrophysiology

Conditions: Photophobia; Traumatic Brain Injury; Migraine

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Healthy Control subjects

Inclusion Criteria

  • Healthy individuals with normal eye exam in the previous year
  • Age 18-80

Exclusion Criteria

  • History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and/or hypertension that are not well controlled, history of head trauma, concussion, or TBI, history of cervical or spinal injury/surgery
  • Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics
  • Must not be light sensitive or get migraine headaches

TBI patients without photosensitivity or headache:

Inclusion Criteria

  • Age 18-80
  • Traumatic Brain Injury (TBI)

Exclusion Criteria

  • History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and/or hypertension that are not well controlled
  • Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics - Must not be light sensitive or get migraine headaches (use headache criteria from Ana if we are including headaches)

Patients with photosensitivity from non-TBI causes Inclusion Criteria

  • Age 18-80
  • Photosensitivity: determined by patient reporting symptoms and there may or may not be an identified cause associated with their light sensitivity (i.e. history of uveitis, childhood exotropia, meningitis, radiation, tumor)

Exclusion Criteria

  • History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and/or hypertension that are not well controlled, history of head trauma, concussion, or TBI, history of cervical or spinal injury/surgery
  • Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics

TBI patients with photosensitivity Inclusion Criteria

  • Age 18-80
  • Photosensitivity: determined by patient reporting symptoms and cause associated with their light sensitivity is post TBI
  • TBI

Exclusion Criteria

  • History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and/or hypertension that are not well controlled

Recruiting US locations

Study contacts (from the official record)

  • Julie Nellis, BSN · 319-356-2780 · julie-nellis@uiowa.edu
  • Jan Full, BSN · 3193562780 · jan-full@uiowa.edu
All neurology studies in Iowa →
Objectively Diagnose and Monitor Treatment of Light Sensitivity (NCT03694626) | Bored Studies