Observational Assessment of Skin Appearance Changes During PRX S Cosmetic Treatment in Participants With Acne-Prone Skin

Inclusion Criteria

• Age 18 years or older at the time of informed consent.
• Presence of acne-prone skin characteristics defined as an IGA score of 1 (almost clear) to 3 (moderate) at baseline (T0).
• Willing and able to commit to 5 in-office treatment sessions at approximately 2-week intervals over approximately 8 weeks, plus one follow-up visit at Week 10.
• Willing to discontinue all current skincare products and adhere exclusively to the WiQo standardized home care regimen throughout the study period. The participant's current skincare regimen must be, in the investigator's judgment, safe to discontinue on the day of the first treatment session without requiring a prior washout period.
• Able to understand and willing to sign the informed consent form prior to any study procedure.
• In general good health as determined by medical history and investigator judgment.
• Ability to read and understand English at a level sufficient to provide written informed consent and complete all study questionnaires independently.

Exclusion Criteria

• IGA score of 0 (clear) or 4 (severe) at baseline.
• Active skin infection, open wounds, or acute inflammatory dermatological conditions in the facial treatment area at the time of enrollment.
• History of hypersensitivity or known allergy to any component of the PRX S formulation or the WiQo home care products.
• Use of systemic retinoids within 6 months prior to enrollment.
• Use of systemic antibiotics for acne within 4 weeks prior to enrollment.
• Ongoing use of topical prescription acne medications (retinoids, topical antibiotics, dapsone) that the participant is unwilling or unable to discontinue.
• Pregnancy, breastfeeding, or planned pregnancy during the study period. Pregnancy status is determined by participant self-report at screening and confirmed through the signed Informed Consent Form, in which the participant acknowledges that pregnancy constitutes a contraindication to the study treatment.
• Prior cosmetic or aesthetic treatment of the face (chemical peel, laser, microneedling, injectables) within 4 weeks prior to enrollment, or prior treatment of the chest or back within 4 weeks prior to enrollment that, in the investigator's judgment, could confound GAGS assessments.
• Any active medical condition that, in the investigator's judgment, could confound study assessments or place the participant at undue risk.
• Participation in another interventional clinical study within 30 days prior to enrollment.
• Inability or unwillingness to comply with study procedures and follow-up requirements.