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Ocular Blood Flow Imaging for Glaucoma Assessment

University of Maryland, Baltimore · with National Eye Institute (NEI), Vasoptic Medical, Inc · NCT05726058

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–88 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
150
US sites recruiting
1
Study start
March 30, 2023
Record last updated
July 2, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to investigate the use of an FDA-cleared retinal blood flow imaging instrument called the XyCAM RI and XyCAM FC (Vasoptic Medical, Inc., Columbia, MD) in glaucoma management.

The main question it aims to answer are

  • Can the investigators use blood flow to discriminate between eyes with early-stage glaucoma and variable-matched controls?
  • Can the investigators validate that the XyCAM FC simultaneously captures both stereo fundus photography and ocular blood flow monitoring?

Participants will be

  • measured for their blood pressure, heart rate, height, and weight
  • dilated with tropicamide
  • imaged using the XyCAM RI, fundus photography, optical coherence tomography, and standard automated perimetry
  • imaged using the XyCAM RI while inhaling 100% oxygen through a mask

Being studied: XyCAM with oxygen

Conditions: Glaucoma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age 18 and older with binocular vision
  • Able to provide informed consent
  • Patient is a healthy control OR is recommended for glaucoma assessment OR diagnosed with moderate to severe glaucoma in at least one eye as determined by Hodapp Anderson Criteria

Exclusion Criteria

  • The subject has significant media opacity (e.g., a visually significant cataract or significant corneal scar)
  • The subject has previous ocular surgery other than uncomplicated cataract extraction, laser trabeculoplasty (ALT or SLT), or YAG capsulotomy
  • The subject has prior ocular disease other than glaucoma
  • The subject has anatomically narrow angles or a prior adverse reaction to administration of Tropicamide or fluorescein dye
  • The subject has more than 15 diopters of refractive error
  • The subject is a female who is pregnant or nursing
  • The subject has diabetes mellitus

Recruiting US locations

  • University of Maryland Eye Associates at Redwood

    Baltimore, MD 21201

    Site contact: Osamah Saeedi, MD, MS

Study contacts (from the official record)

  • Osamah J Saeedi, MD, MS · (410) 328-5929 · osaeedi@som.umaryland.edu
All healthy volunteers studies in Maryland →
Ocular Blood Flow Imaging for Glaucoma Assessment (NCT05726058) | Bored Studies