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RecruitingAccepts healthy volunteersEarly Phase 1

Optic Nerve Head Strain in Non-glaucoma Subjects

Johns Hopkins University · with National Eye Institute (NEI) · NCT07425535

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 30–90 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
30
US sites recruiting
1
Study start
June 24, 2026
Record last updated
July 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Persons who do not have glaucoma will have pictures taken of the optic nerve with a standard camera before and 2 weeks after starting to take a daily glaucoma eye drop to lower eye pressure. These data will be used to compare to the same procedure performed with glaucoma patients to study how glaucoma injures the eye.

Being studied: Latanoprost (0.005%)

Conditions: Glaucoma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adults who have no history of OAG
  • Have an ocular examination by a glaucoma specialist with no indications of OAG
  • Have normal optical coherence tomography findings in the retinal nerve fiber layer.
  • Over age 30 will be included from
  • Both sexes
  • All ethnic groups.
  • Optic neuropathy.
  • Both suspects and those with glaucoma damage will be included.
  • When both eyes meet inclusion and exclusion criteria, both eyes will be included in the study and statistical methods will be used to account for correlations between eyes within the same individual.

Exclusion Criteria

  • in whom sitting in an upright position is impossible due to physical disability
  • with ocular media opacity, corneal scarring, cataract or vitreous hemorrhage, that does not allow adequate imaging resolution.
  • in whom keeping the eyes open during the imaging procedure is not possible or uncomfortable.
  • who cannot perform home tonometry accurately at certification
  • who do not have reliable clinical Optical Coherence Tomography (OCT) testing.
  • with any form of glaucoma
  • with high myopia defined as refractive error > -8
  • with past keratorefractive surgery, corneal dystrophy, or corneal ectasia that would make self-tonometry measurements difficult to interpret
  • inability to understand English or with a language or hearing impairment

Recruiting US locations

  • Johns Hopkins Hospital

    Baltimore, MD 21287

    Site contact: Harry Quigley · 443-742-7079 · hquigley@jhmi.edu

Study contacts (from the official record)

  • Harry A Quigley, MD · 410 955 6051 · hquigley@jhmi.edu
  • Farzaneh Dadvar, MD · fdadvar1@jh.edu
All healthy volunteers studies in Maryland →
Optic Nerve Head Strain in Non-glaucoma Subjects (NCT07425535) | Bored Studies