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Overlapping Pain Trajectory Study

Children's Hospital Medical Center, Cincinnati · NCT05752396

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 10–19 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
420
US sites recruiting
1
Study start
March 1, 2023
Record last updated
October 20, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are:

  • If spatial and temporal filtering of nociceptive information is disrupted in youth with COPCs compared with youth with localized pain conditions and healthy controls.
  • If disrupted nociceptive processing at baseline is associated with the transition from a single localized pain condition to COPCs in youth.

Participation includes

  • quantitative sensory testing
  • blood draw
  • sleep assessment
  • questionnaires

Being studied: Conditioned Pain Modulation; Offset Analgesia; Spatial Summation; Temporal Summation

Conditions: Migraine; Musculoskeletal Pain; Functional Abdominal Pain Disorders; Chronic Pain; Widespread Chronic Pain; Low Back Pain; Healthy Volunteers

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • General Criteria
  • Access to the internet either by laptop, tablet, or phone (for REDCap Surveys)
  • English-speaking
  • Parent or guardian willing to comply with protocol, complete study assessments, and provide written informed consent
  • Control Specific Criteria
  • No history/active chronic pain
  • Patient Specific Criteria
  • Patients will need a diagnosis of a chronic pain derived congruent with ICD-11 criteria related to headache (migraine, daily headache), abdominal (FAPD), localized MSK (single limb/joint, low back or chest pain), or diffuse MSK (widespread MSK pain)
  • If on medications, they need to be on stable doses of prescribed pain and/or psychiatric medications for 4 weeks before the baseline study visit.

Exclusion Criteria

  • General Criteria
  • Skin conditions (e.g., eczema) or past skin damage on the arms and legs in or near sites of sensory testing
  • Any comorbid rheumatic disease (e.g., arthritis, lupus), neurological (e.g., epilepsy, traumatic brain injury) or medical condition (e.g., cancer, diabetes)
  • Control Specific Criteria
  • Taking medications that can alter pain sensitivity (e.g., NSAIDs, opioids, stimulants, anticonvulsants; psychiatric)
  • Patient Specific Criteria
  • Present psychiatric disease as defined by DSM IV (e.g. psychosis, bipolar disorder, major depression, generalized anxiety disorder), alcohol or drug dependence, or documented developmental delays or impairments (e.g., autism, cerebral palsy, ADHD, or mental retardation) that, in the opinion of the investigator, would interfere with adherence to study requirements or safe participation in the study

Recruiting US locations

  • Cincinnati Children's Hospital

    Cincinnati, OH 45229

    Site contact: Christopher D King, Ph.D. · 5138032391 · christopher.king@cchmc.org

Study contacts (from the official record)

  • Kacie Peters · 513-517-0594 · Kacie.Peters@cchmc.org
  • Catherine Jackson · 513-636-0669 · Catherine.Jackson@cchmc.org
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Overlapping Pain Trajectory Study (NCT05752396) | Bored Studies