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Oxalate and Citrate in Humans - Response to Citrate

University of Chicago · with National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NCT06944223

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–70 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
24
US sites recruiting
1
Study start
October 1, 2025
Record last updated
December 16, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is a single-center study that aims to learn more about how two compounds found in food, oxalate and citrate, interact in the body and may influence a person's chances of forming kidney stones. The study will examine changes in urinary oxalate and citrate levels after participants consume potassium citrate.

Being studied: Kidney stone formers; Control cohort

Conditions: Kidney Stone; Healthy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Stone formers (SF):

  • Age 18-70
  • History of at least one calcium-based kidney stone

Non-stone formers (NSF):

  • Age 18-70
  • No history of kidney stone
  • 24-hour urine oxalate within laboratory normal range (\<50 mg/day)

Exclusion Criteria

History of primarily uric acid, cysteine, or struvite stones

History of severe acid-base abnormality, very low (less than 100 mg/day) or very high (greater than 1500 mg/day) urine citrate

Any controls or stone former (SF) participants who cannot stop diuretic medication or alkali supplementation for the course of the study period

Chronic kidney disease (glomerular filtration rate \<75 milliliters per minute per 1.73 square meters [mL/min/1.73 m²])

Non-stone formers (NSF) and stone formers (SF) with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.

Recruiting US locations

  • University of Chicago Medical Center

    Chicago, IL 60637

    Site contact: Megan Prochaska, MD · 773-702-1000 · mprocha2@medicine.bsd.uchicago.edu

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Oxalate and Citrate in Humans - Response to Citrate (NCT06944223) | Bored Studies