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Oxalate and Citrate

University of Chicago · NCT05334979

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Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–70 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
50
US sites recruiting
1
Study start
October 27, 2022
Record last updated
January 8, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.

Being studied: Kidney stones Normal controls Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic

Conditions: Kidney Stone; Normal Controls

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Stone formers

  • Age 18-70
  • History of at least one calcium-based kidney stone

Non-stone formers (controls):

  • Age 18-70
  • No history of kidney stone
  • 24-hour urine oxalate within lab normal (\<50mg/day)

Exclusion Criteria

  • History of primarily uric acid, cysteine, or struvite stones.
  • History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate.
  • Any controls or stone-forming participants who cannot stop diuretic medication or alkali supplementation for the course of the study period.
  • Non-stone formers and stone-formers with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.

Recruiting US locations

  • University of Chicago Medical Center

    Chicago, IL 60637

    Site contact: Megan Prochaska, MD · (773) 702-1000 · mprocha2@medicine.bsd.uchicago.edu

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Oxalate and Citrate (NCT05334979) | Bored Studies