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RecruitingAccepts healthy volunteersPhase 4

Oxytocin and Fetal Heart Rate Changes

Unyime Ituk · NCT03232918

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–55 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
730
US sites recruiting
1
Study start
February 20, 2019
Record last updated
June 4, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The reported risk of nonreassuring fetal heart trace following neuraxial analgesia is 3-23%. This variability may be due to fluid and oxytocin management prior to and during the initiation of neuraxial analgesia. The study hypothesis is that decreasing the oxytocin infusion rate by 50 % prior to initiation of combined spinal epidural analgesia will cause a reduction in the incidence of adverse fetal heart rate changes.

Being studied: Half dose Oxytocin

Conditions: Fetal Bradycardia Complicating Labor and Delivery; Fetal Bradycardia During Labor; Fetal Heart Rate or Rhythm Abnormality Affecting Fetus

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Healthy nulliparous or multiparous women at term (37 > weeks' gestation)
  • Singleton pregnancy
  • Request for neuraxial analgesia
  • Oxytocin used for induction of labor or augmentation of labor per institutional protocols

Exclusion Criteria

  • Use of chronic analgesic medications
  • Prior administration of systemic opioid labor analgesia
  • Non-vertex presentation
  • Contraindication to neuraxial analgesia
  • Category 3 fetal heart rate tracing prior to the initiation of combined spinal epidural analgesia

Recruiting US locations

  • University of Iowa Hospitals and Clinics

    Iowa City, IA 52245

    Site contact: Unyime Ituk, MD · 319-356-2633 · unyime-ituk@uiowa.edu

Study contacts (from the official record)

  • Unyime Ituk · 319-356-2633 · unyime-ituk@uiowa.edu
All healthy volunteers studies in Iowa →
Oxytocin and Fetal Heart Rate Changes (NCT03232918) | Bored Studies