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Patients With and Without Phonotrauma

University of Texas Southwestern Medical Center · NCT05625191

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
100
US sites recruiting
1
Study start
January 17, 2023
Record last updated
June 11, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

There is a substantial need to identify objective measures associated with hyperadduction of the vocal folds to recognize those at higher risk of developing phonotrauma so that risk mitigation strategies can be implemented before phonotrauma develops. The overall objective of this proposed project is to investigate the sensitivity and direction of change in cepstral peak prominence (CPP) and the magnitude difference between the first two harmonics of the voice spectrum (H1-H2) in response to varied phonation patterns, which will be addressed using the following two aims:

Aim 1: Determine how CPP and H1-H2 change as a function of using pressed voice production in individuals without laryngeal pathology.

Aim 2: Examine the sensitivity (minimally detectable change) and responsiveness (minimal clinically important difference) of CPP and H1-H2 to detect changes in different voice production conditions.

Being studied: Acoustic voice analysis; High-speed videoendoscopy

Conditions: Phonotrauma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Control Group

Inclusion Criteria

  • 18-65 years of age (to avoid confounding physiological factors related to puberty or presbyphonia)
  • No history of or current voice disorder
  • Auditory perceptual presentation globally within functional limits (as determined by a voice specialized SLP).

Exclusion Criteria

  • Atypical auditory-perceptual voice presentation
  • History of voice disorder or laryngeal surgery.

Patient Group

Inclusion Criteria

  • Diagnosed with phonotrauma (i.e., vocal fold nodules, vocal fold polyp, vocal fold pseudocyst, mid-fold edema) by a laryngologist.
  • 18-65 years of age

Exclusion Criteria

  • Diagnosis of voice disorder not related to phonotrauma (e.g., vocal fold immobility, laryngeal dystonia, primary muscle tension dysphonia, etc.)
  • Previous history of laryngeal surgery or voice therapy (to avoid confounding effects of previous treatment).

Recruiting US locations

  • UT Southwestern Medical Center

    Dallas, TX 75235

    Site contact: Laura Toles · 2146452943 · Laura.Toles@UTSouthwestern.edu

Study contacts (from the official record)

  • Laura Toles, PhD · 214-645-2943 · Laura.Toles@UTSouthwestern.edu
  • Paula Arellano-Cruz · 214-648-8096 · paula.arellano-cruz@utsouthwestern.edu
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Patients With and Without Phonotrauma (NCT05625191) | Bored Studies