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Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section

Senthil Sadhasivam · with National Center for Advancing Translational Sciences (NCATS) · NCT05380531

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
700
US sites recruiting
3
Study start
December 5, 2022
Record last updated
September 10, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in breastfeeding mothers and their infants

Being studied: Preoperative Genotyping

Conditions: Cesarean Section Complications; Opioid Use

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Adult women (>18 yr) All races American Society of Anesthesiologists Classification (ASA) physical status: 1 to 3 undergoing elective Cesarean section that are willing to receive in-patient opioids.

Exclusion Criteria

  • Health conditions including uncontrolled diabetes (gestational or pre-existing) or hypertension (pre-eclampsia, eclampsia, or chronic)
  • Any history of opioid misuse before or during pregnancy-per self-report and clinical notes
  • Preoperative severe pain and opioid use/misuse, allergy to oxycodone
  • Allergy to oxycodone
  • Significant neurological disorders, liver and renal diseases

Recruiting US locations

  • Riley Children's Hospital- Clinics / Labor and Delivery Unit

    Indianapolis, IN 46202

    Site contact: David M. Haas, MD · 317-880-3960 · dahaas@iu.edu

  • Washington University Hospital

    St Louis, MO 63110

    Site contact: Arvind Palanisamy, MD · 314-362-2330 · arvind.palanisamy@wustl.edu

  • University of Pittsburgh

    Pittsburgh, PA 15260

    Site contact: Amy Monroe, MPH · 412-623-6382 · monroeal@upmc.edu

Study contacts (from the official record)

  • Senthilkumar Sadhasivam, MD, MPH · 4126472994 · sadhasivams@upmc.edu
  • Dayana Alsamsam, MPH · alsamsamd@upmc.edu
All pregnancy studies in Indiana →
Personalized Perioperative Analgesia Platform (PPAP) for Cesarean… (NCT05380531) | Bored Studies