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Personalized Theta-burst Stimulation for Long-lasting Changes in Approach/Avoidance Behavior

Northwestern University · with National Institute of Mental Health (NIMH) · NCT07161505

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Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
26
US sites recruiting
1
Study start
July 31, 2025
Record last updated
August 18, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study will assess the long-lasting effects of personalized theta burst stimulation (TBS), a repetitive form of transcranial magnetic stimulation (TMS), over the left prefrontal cortex on the approach/avoidance behavior. TBS will be personalized based on the prefrontal theta rhythm captured with electroencephalography (EEG). The main questions it aims to answer are: 1. does a single session of personalized TBS synchronized with the individual theta rhythm over the left prefrontal cortex results in the outlasting changes in the individual behavior? 2. Does TBS results in the brain rhythms' changes as measured using resting-state EEG?

Being studied: TBS-EEG; TBS-EEG / Spatial Control; TBS / Temporal Control; TBS-EEG / Dose Control

Conditions: Approach/Avoidance Behavior

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Participants must be legal adults between the ages of 18 to 65;
  • Able and willing to complete study procedures and tasks.

Exclusion Criteria

  • History or evidence of chronic neurological or mental disorder;
  • Chronic condition that requires pharmacological treatment over the course of study participation;
  • Pregnancy or breastfeeding;
  • History or evidence of alcohol or drug addiction;
  • Contraindications for transcranial magnetic stimulation (history of seizures, metallic or electric implant in the head/neck area);
  • Contraindications for magnetic resonance imaging at 3 Tesla (non-compatible implants, metallic foreign bodies, insulin pump, pacemaker).

Recruiting US locations

  • Northwestern University Feinberg School of Medicine

    Chicago, IL 60611

    Site contact: Ivan Alekseichuk, PhD · 312-503-3196 · neuromodlab@northwestern.edu

Study contacts (from the official record)

  • Ivan Alekseichuk, PhD · 312-503-3196 · neuromodlab@northwestern.edu
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Personalized Theta-burst Stimulation for Long-lasting Changes in… (NCT07161505) | Bored Studies