Pharmacological Modulation of Brain Oscillations in Memory Processing

Patient inclusion criteria

• Age 18 - 55 years, all races/ethnicities, and both genders are eligible.
• Candidates for pre-operative evaluation using stereo intracranial electrodes and admission to the Epilepsy Monitoring Unit (EMU) as determined independently by the patient's treating physician as part of the patient's routine medical care.
• Able to read, understand, and provide written, dated informed consent prior to screening.
• In good general health, aside from a history of epilepsy, as ascertained by medical history, physical examination (PE), clinical laboratory evaluations, and ECG.
• Body mass index between 18-35 kg/m2.

Patient exclusion criteria

• Has a clinically significant abnormality on the screening physical examination that might affect safety, study participation, or confound interpretation of study results according to the study physician.
• Female that is pregnant, breastfeeding, or has a positive pregnancy test at screening or baseline. Note that pregnant patients are excluded from undergoing iEEG generally and all patients undergo a positive screening urine test for drugs of abuse at screening: cannabinoids, cocaine, amphetamines, barbiturates, opiates not otherwise explained by their prescribed medications.
• History of renal insufficiency.
• Unstable cardiac syndrome or active cardiac symptoms.
• Patients with liver failure.
• Patients with BPH.
• Patients with autoimmune neuropathy.
• Patients with uncontrolled hyperthyroidism.
• Patients with a history of dementia.
• Patient with a history of delirium after using transdermal scopolamine.
• History of narrow-angle glaucoma.
• History of pyloric obstruction or paralytic ileus.
• History of myasthenia gravis, obstructive uropathy, porphyria, or myasthenia gravis.