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Phenotyping Genetic Risk for Type 2 Diabetes

University of Pennsylvania · NCT04024631

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 10–70 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
100
US sites recruiting
1
Study start
June 17, 2019
Record last updated
September 21, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.

Being studied: 75g glucose beverage (Glucola, Trutol, or similar brand); DXA, whole body

Conditions: Diabetes Mellitus, Type 2; Genetics

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age 10-70 years
  • Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research.
  • Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher

Exclusion Criteria

  • prior diagnosis of type 1, type 2, or secondary diabetes
  • use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication
  • acute illness that may impact insulin and glucose dynamics
  • pregnancy
  • hypothalamic obesity or related genetic disorder of metabolism
  • recent systemic chemotherapy use
  • gastrointestinal impairment or surgery that may impact absorption
  • anemia
  • major organ system illness or any underlying condition requiring regular medication or treatment that could make implementation of the protocol or interpretation of the study results difficult
  • inability to comply with study protocol

Recruiting US locations

  • University of Pennsylvania

    Philadelphia, PA 19104

    Site contact: Jessica R Wilson, MD, MS · 215 898-3389 · jessica.wilson3@uphs.upenn.edu

Study contacts (from the official record)

  • Jessica R Wilson, MD, MS · 215 898-3389 · jessica.wilson3@uphs.upenn.edu
  • Esther Oyerinde · esther.oyerinde@pennmedicine.upenn.edu
All diabetes studies in Pennsylvania →
Phenotyping Genetic Risk for Type 2 Diabetes (NCT04024631) | Bored Studies