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Platelet Volunteers, Longitudinal and Multi-omic Study

National Heart, Lung, and Blood Institute (NHLBI) · NCT07137429

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–100 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
400
US sites recruiting
1
Study start
March 26, 2026
Record last updated
July 31, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Background

Platelets are a type of blood cell that play a critical role in bleeding, forming blood clots, and healing. Researchers want to know more about platelets work in healthy people. They want to look at how platelets clump together, how blood clots, and how genes and proteins work. They also want to study how these processes change over time and how they are affected by factors such diet, exercise, weight, and new health problems.

Objective

To study how platelets function in healthy people.

Eligibility

Healthy people aged 18 years and older.

Design

Researchers will review participants medical history. They will ask about the participant s family history and any drugs they take.

Participants will have a clinic visit once every 6 or 7 months for 10 years. Each visit will be 2 to 3 hours.

At each visit, participants will have several tests and procedures:

A physical exam, including vital signs. Hip and ankle circumference will be measured.

Urine collection.

Blood tests. About 10 tablespoons of blood will be drawn. Participants will be asked to fast for 10 hours and avoid drugs like aspirin or Advil for 7 days before each draw. Some of the blood may be used for gene studies. Some may be used to create stem cells for research. Stem cells are cells that can be used to make other types of cells.

Surveys and questionnaires. Participants will answer questions about habitual activity, diet, smoking, drugs and alcohol, sleep, illness, and other health issues. These surveys may be done online, via email, or by phone.

Conditions: Thrombosis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria
  • INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

  • Stated willingness to comply with all study procedures, including fasting at least 10 hours before each blood draw
  • Stated willingness to refrain from aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) for 7 days prior to any visits
  • Age >= 18 years
  • In good general health as evidenced by self-reported medical history

EXCLUSION CRITERIA

An individual who, by self-report, meets the following criteria will be excluded from participation in this study:

  • Current pregnancy or lactation
  • Active malignancies known, active known auto-immune disease, known major CVD (e.g., heart attack, stroke, venous thromboembolism, heart failure), severe bleeding history, on regular P2Y12 inhibitors or other antiplatelet treatments for a clinical reason, uncontrolled hypertension or diabetes

Recruiting US locations

  • National Institutes of Health Clinical Center

    Bethesda, MD 20892

    Site contact: NIH Clinical Center Office of Patient Recruitment (OPR) · 800-411-1222 · ccopr@nih.gov

Study contacts (from the official record)

  • Jayson J Grey, R.N. · (240) 401-6378 · jayson.grey@nih.gov
  • Andrew D Johnson, Ph.D. · (508) 663-4082 · johnsonad2@mail.nih.gov
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Platelet Volunteers, Longitudinal and Multi-omic Study (NCT07137429) | Bored Studies