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RecruitingAccepts healthy volunteers

Pneumococcal Carriage Duration

University of Central Florida · with Merck Sharp & Dohme LLC · NCT07748832

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 1 mo–4 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
60
US sites recruiting
1
Study start
July 21, 2026
Record last updated
August 6, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Streptococcus pneumoniae (SPN) remains a leading cause of respiratory disease in young children despite widespread vaccination. Understanding the duration of pneumococcal carriage, patterns of co-colonization, and the influence of viral infections and the respiratory microbiome is essential to evaluate next-generation pneumococcal vaccines and inform public health strategies. Current data on Streptococcus pneumoniae carriage dynamics are limited in U.S. pediatric populations. This study aims to generate updated estimates of Streptococcus pneumoniae colonization and explore microbial interactions using high-resolution longitudinal sampling and genomic methods.

Being studied: Oropharyngeal (OP) swab

Conditions: Pneumococcal Carriage

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Are older than 28 days and under 4 years of age at the time of enrollment.
  • Have a parent or legal guardian who:
  • Provides written informed consent.
  • Is able to read and speak English or Spanish.
  • Agrees to comply with all study procedures, including completion of questionnaires and biweekly oropharyngeal (OP) swab collections from the child for a period of 12 months.

Exclusion Criteria

  • History of chronic medical conditions or immunocompromising conditions that may influence pneumococcal carriage or study participation, such as:
  • cystic fibrosis
  • cerebral palsy
  • neuromuscular disorders
  • congenital heart disease
  • known congenital or acquired immunodeficiencies
  • sickle cell disease
  • undergoing immunosuppressive therapy (e.g., systemic corticosteroids ≥2 mg/kg/day for ≥14 days, chemotherapy, biologics)

Recruiting US locations

  • University of Central Florida

    Orlando, FL 32827

    Site contact: Dr. Amoy Fraser, PhD · 407-266-8742 · Amoy.Fraser@UCF.edu

Study contacts (from the official record)

  • Dr. Amoy Fraser, PhD · 407-266-8742 · Amoy.Fraser@UCF.edu
  • Aniya Barclay, MS · 407-266-8742 · Aniya.Barclay@UCF.edu
All healthy volunteers studies in Florida →
Pneumococcal Carriage Duration (NCT07748832) | Bored Studies