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RecruitingAccepts healthy volunteersEarly Phase 1

Positron Emission Tomography (PET) Imaging of Cholesterol Trafficking: Clinical Evaluation of [18F]FNP-59 in Normal Human Subjects (Group 1)

Benjamin Viglianti · NCT04532489

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
6
US sites recruiting
1
Study start
January 18, 2021
Record last updated
December 5, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This exploratory, first-in-man, phase 0 study will evaluate the feasibility of using a sub-therapeutic dose of a fluorine-18 analogue of NP-59 ([18F]FNP-59) to image the adrenal gland in healthy normal subjects. The researchers believe that [18F]FNP-59 would greatly improve the imaging characteristics, by providing a PET imaging cholesterol analogue with significantly improved radiation dosimetry.

Being studied: FNP-59

Conditions: Radiotracer; Hypertension; Cholesterol

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Participants without any known adrenal pathology as normal controls for radiation dosimetry purposes

Exclusion Criteria

  • Pregnancy
  • Unable to do imaging
  • Body weight greater than 400 lbs (181 Kg)
  • Prisoners are not eligible
  • Subjects unable to provide own consent are not eligible
  • Current use of steroids, Oral contraceptives (OCP), spironolactone, estrogen, androgen, progesterone, Angiotensin-converting enzyme (ACE inhibitors)/ Angiotensin II receptor blockers (ARBs), or supplements that are hormone analogues.
  • Known adrenal pathology

Recruiting US locations

  • University of Michigan

    Ann Arbor, MI 48109

    Site contact: James Pool · 734-615-7391 · jampool@umich.edu

Study contacts (from the official record)

  • Jim Pool · 734-615-7391 · jampool@umich.edu
All heart & blood pressure studies in Michigan →
Positron Emission Tomography (PET) Imaging of Cholesterol… (NCT04532489) | Bored Studies