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Postprandial Effects of Fresh Mango as a Table Sugar Replacement in High-Sugar Breakfasts.

Ball State University · with National Mango Board · NCT07650058

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–45 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
35
US sites recruiting
1
Study start
February 1, 2026
Record last updated
June 16, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Systemic inflammation and intestinal hyperpermeability (disruption of the gut barrier which allows nutrient molecules and bacteria to enter the bloodstream) are triggered by consumption of high-sugar meals and are linked to future development of cardiovascular disease (CVD). Previous research indicates that fresh mangos have properties that have positive effects on the intestinal barrier and local gut inflammation. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to decreased inflammatory and permeability biomarkers after eating a high-sugar breakfast. The investigators will compare the postprandial (post meal) levels of inflammatory (IL-6) and permeability (LPS, lipid binding protein (LBP), and soluble CD14) biomarkers in blood from participants who have consumed a meal sweetened with either sucrose or fresh mango.

Being studied: High-Glycemic Breakfast Containing Cereal and Fresh Mango; High-Glycemic Breakfast Containing Cereal and Table Sugar

Conditions: Healthy Participants

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 18 - 45 years.
  • Body mass index between 18.5-35.0 kg/m2
  • Not pregnant or expecting to become pregnant (females only)
  • Not postmenopausal (females only).
  • No known chronic medical conditions (e.g., type 2 diabetes, cardiovascular disease, inflammatory diseases, etc.)
  • No history of using tobacco/illicit drugs
  • No history of using glucose-lowering medications/supplements.
  • No history of using prescribed anti-inflammatory medications
  • Does not use over-the-counter anti-inflammatory medications ≥2x/week
  • Does not have a pacemaker.
  • No relevant food allergies/intolerances
  • Able to lay supine for at least ten minutes.

Exclusion Criteria

  • Not between the ages of 18-45
  • Body mass index \< 18.5 kg/m2 or >35.0 kg/m2
  • Pregnant (females only)
  • Postmenopausal status (females only).
  • Been diagnosed with a chronic medical conditions (e.g., type 2 diabetes, cardiovascular disease, inflammatory diseases, etc.)
  • Uses tobacco products or any illicit drugs.
  • Uses glucose-lowering drugs/supplements.
  • Regularly takes anti-inflammatory drugs (more than 2x week).
  • Have a pacemaker.
  • Allergic to mango, wheat, gluten, and/or milk.
  • Unable to lay in supine position in the dark for at least ten minutes.

Recruiting US locations

  • Health Professions Building, Ball State University

    Muncie, IN 47306

    Site contact: Bryant Keirns, PhD · 765-285-8356 · bryant.keirns@bsu.edu

Study contacts (from the official record)

  • Bryant Keirns, PhD · 765-285-8356 · bryant.keirns@bsu.edu
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Postprandial Effects of Fresh Mango as a Table Sugar Replacement… (NCT07650058) | Bored Studies