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Potatoes, Type 2 Diabetes, and Cardiometabolic Health

Virginia Polytechnic Institute and State University · NCT07229482

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 50–70 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
42
US sites recruiting
1
Study start
August 27, 2026
Record last updated
September 3, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Type 2 diabetes (T2D) is a major chronic health condition which increases risk of coronary artery disease, frailty, cognitive decline, and mortality. Additionally, hypertension is a major comorbidity for individuals with T2D, further increasing the risk of adverse cardiovascular outcomes. The prevalence of both conditions increases with advancing age. There is an urgent need to identify new approaches to prevent the development of T2D and improve cardiometabolic health in older adults 50-70 years of age.

Whole white potatoes are an unprocessed food rich in essential nutrients often under-consumed by Americans, including potassium, fiber, magnesium, vitamins C and B6, and phytochemicals. Each of these nutrients individually are associated with cardiometabolic health benefits. Potatoes account for a significant amount of the intake of these nutrients in the US diet and are well-positioned to be a foundational element of a healthy dietary pattern. However, there are few interventional studies evaluating the effect of potatoes on cardiometabolic health, and the evidence from observational studies is mixed, leaving a significant gap in knowledge regarding the potential for potatoes to be included in healthy dietary patterns.

The results of our proposed study will provide foundational data that inform future dietary guidelines regarding the inclusion of white potatoes as part of a healthy US dietary pattern.

Being studied: Controlled diet: Potato-rich healthy dietary pattern; Controlled diet: Typical Western-style dietary pattern

Conditions: T2D; Blood Pressure; Cardiometabolic Health

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age 50-70 years
  • Weight stable for previous 3 months (±5% body weight)
  • Sedentary to recreationally active
  • ADA-Risk Screener questionnaire score of at least 5
  • No plans to gain or lose weight or change physical activity level
  • Willing to pick up food daily and consume foods provided for a 14-week period
  • Verbal and written informed consent
  • Estrogen or testosterone use, lipid-lowering or blood pressure medication and thyroid replacement medication is acceptable, if on stable dose for >6 months

Exclusion Criteria

  • Body mass index >40 m2/kg
  • Diabetes or diabetes medication
  • Weight loss medication or medication influencing glucose metabolism
  • Antibiotic, prebiotic or probiotic use in prior 3 months
  • TCHOL >6.2 mmol/L; TG >4.5 mmol/L
  • Blood pressure (BP) > 159/99 mmHg
  • Diagnosed inflammatory bowel disease
  • Past or current heart diseases, stroke, respiratory disease, endocrine or metabolic disease, or hematological-oncological disease
  • Vegetarian or vegan
  • Pregnant or plans to become pregnant
  • Food allergies or aversions to diet foods provided
  • Estrogen or testosterone usage, lipid-lowering medication, blood pressure medication usage \<6 months

Recruiting US locations

  • Virginia Polytechnic Institute and State University

    Blacksburg, VA 24061

    Site contact: Dennis Cladis, PhD · 540-231-5208 · dcladis@vt.edu

Study contacts (from the official record)

  • Dennis Cladis, PhD · 540-231-5208 · dcladis@vt.edu
  • Elaina Marinik, PhD · 540-231-0923 · emarinik@vt.edu
All diabetes studies in Virginia →
Potatoes, Type 2 Diabetes, and Cardiometabolic Health (NCT07229482) | Bored Studies