Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft

Inclusion Criteria

• Age >18 years
• Good general health (controlled conditions)
• Fluent in English
• Treatment-planned for single site extraction and bone graft surgery

Exclusion criteria

• Pregnancy
• Site with active infection i.e purulence, abscess formation
• Patients experiencing pain pre-operatively
• Oral surgery in more than one site/quadrant in the same session
• Patients receiving surgery under sedation
• Patients with any contraindication for oral bone grafting surgery (e.g., on anticoagulants, medication-related osteonecrosis of the jaw, etc.)
• Patients experiencing acute or chronic oral pain due to conditions or previous interventions
• Patients with diseases or taking medications that affect hard and soft tissue wound healing such as poorly controlled diabetes, bisphosphonate use, corticosteroid use, chemotherapy, immunosuppressive therapy, etc.
• Current or chronic (≥4 weeks) use of anti-inflammatory, analgesic, corticosteroid or sedative medications in the past 6 months
• Health conditions that contraindicate the use of NSAIDs, such as stomach ulcers, bleeding disorders, renal disfunction, liver cirrhosis or acute liver disease, etc.
• Intake of medications that interact with NSAIDs or whose actions can be affected by NSAIDs, such as anticoagulant/antiplatelet medications, ACE inhibitors, diuretics, etc.
• Allergy to ibuprofen, acetaminophen and/or aspirin, and study materials (e.g., sutures, grafts, membranes?).
• Patients having 3 or more alcoholic beverages daily
• Patients who are planned to undergo heart surgery or had heart surgery less than 6 months prior
• Not fluent in English