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PTGS1 Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn

Medical College of Wisconsin · NCT00710177

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Up to age 1 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
200
US sites recruiting
1
Study start
January 2006
Record last updated
January 26, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to determine if normally occurring variations in a specific gene called PTGS-1 are associated with an increased risk of narrowing of the ductus arteriosus from exposure to over-the-counter pain medicines (NSAIDs).

Conditions: Persistent Pulmonary Hypertension of the Newborn

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Infants born greater than or equal to 34 weeks gestational age diagnosed with PPHN and normal, healthy infants born greater than or equal to 34 weeks gestational age.

Exclusion Criteria

  • Patients will be excluded if they are diagnosed with lethal congenital anomalies
  • structural congenital heart disease except presence of patent ductus arteriosus (PDA) or patent foramen ovale
  • structural gastrointestinal tract abnormality that could interfere with meconium passage
  • congenital anomalies such as diaphragmatic hernia, Potter's syndrome, or pulmonary hypoplasia

Recruiting US locations

  • Children's Wisconsin

    Milwaukee, WI 53226

    Site contact: Ganesh Konduri, MD

Study contacts (from the official record)

  • G. Ganesh Konduri, MD · 414-266-6820 · gkonduri@mcw.edu
  • Kathleen M Meskin, BSN · 414-337-7171 · kmeskin@mcw.edu
All heart & blood pressure studies in Wisconsin →
PTGS1 Genetic Variation and Increased Risk for Persistent… (NCT00710177) | Bored Studies