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RecruitingAccepts healthy volunteersEarly Phase 1

Quadriceps Motor Unit Adaptation to Simulated Knee Injury

University of Central Florida · NCT06999057

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–30 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
45
US sites recruiting
1
Study start
August 1, 2026
Record last updated
May 1, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults. Participants will complete neuromuscular testing during a single 2-hour lab session. This research seeks to improve understanding of muscle inhibition and inform interventions after real-world knee trauma.

Being studied: Joint Effusion via 60 mL Sterile Saline; Intra-articular Lidocaine; Sham injection

Conditions: Muscle Inhibition; Knee Injury Simulation

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age 18-30 years
  • Physically active (Tegner ≥ 5)
  • No prior lower-limb surgery or major injury

Exclusion Criteria

  • Lower limb surgery or significant injury in past 2 years
  • Cardiopulmonary, neurological, or psychiatric disorders
  • Needle/electrical stimulation anxiety
  • Medications affecting neuromuscular or psychological function
  • Pregnancy
  • Allergic to lidocaine
  • Inability to elicit Hoffmann reflex

Recruiting US locations

  • University of Central Florida

    Orlando, FL 32816

    Site contact: Grant E. Norte · 407-823-3188 · Grant.Norte@ucf.edu

Study contacts (from the official record)

  • Grant Norte, Ph.D. · 407-823-3188 · Grant.Norte@ucf.edu
  • Meredith Chaput, Ph.D. · Meredith.Chaput@ucf.edu
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Quadriceps Motor Unit Adaptation to Simulated Knee Injury (NCT06999057) | Bored Studies