RecruitingAccepts healthy volunteers

Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release

Dartmouth-Hitchcock Medical Center · NCT06330545

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

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The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are:

Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment with Collagenase Clostridium Histolyticum?

Participants will undergo

Release of Dupuytren's Contracture after Collagenase Clostridium Histolyticum injection
Daily radiation therapy treatment for 5 days followed by 6-8 week rest period and then another course of 5 days of radiation therapy

Being studied: Radiation therapy

Conditions: Dupuytren Contracture

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Age 45 or greater with DC
Extension deficit >10 degrees
Unable to simultaneously place the affected finger and palm flat on a table.
Women included in the study will be post-menopausal or using contraception, and a pregnancy test will be performed as standard of care.
For patients who are having multiple CCH injections, only the first 2 joints on given hand will be included

Exclusion Criteria

Unsuccessful non-surgical release (> N/1 disease)
They develop an open wound during CCH
Breast feeding or pregnancy
A chronic muscular, neurologic, or neuromuscular disorder affecting the hands.
Less than the age of 45
They have previously undergone radiation on the hand in which they plan to get CCH injections
They are pregnant women, impaired adults or prisoners

Dartmouth Hitchcock
Lebanon, NH 03766
Site contact: Julia Schwarz, MD · 6036505133 · julia.s.schwarz@hitchcock.org