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Regional Phenotyping of CF and Non-CF Bronchiectasis

Children's Hospital Medical Center, Cincinnati · NCT04793867

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 5–100 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
100
US sites recruiting
1
Study start
February 8, 2021
Record last updated
October 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy response. The Investigator's central hypothesis is that image-based markers can forecast pathophysiology prior to spirometric changes.

Being studied: Xenon

Conditions: Cystic Fibrosis; Non-CF Bronchiectasis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • CF Patients: Diagnosis of CF based on sweat chloride >60 mMol/l
  • Presence of two disease causing CFTR mutations, or end organ manifestations of disease.
  • Age minimum 5 years.
  • Care provided by the CCHMC CF Care Center or other regional CF Care Centers if required to achieve recruitment goals.

Exclusion Criteria

  • Patients meeting standard MRI exclusions criteria (non-MRI-compatible metal implants, claustrophobia, etc.)
  • Pregnancy or lactation.

Inclusion Criteria of Healthy Subjects

  • Subjects 5 years of age and older with no known history of cardiopulmonary disease.

Exclusion Criteria of Healthy Subjects

  • Patients meeting standard MRI exclusions criteria (non-MRI-compatible metal implants, claustrophobia, etc.)
  • Pregnancy or lactation.

Recruiting US locations

  • Penny New

    Cincinnati, OH 45229

    Site contact: Penny A New, BBA · 513-332-7931 · penny.new@cchmc.org

Study contacts (from the official record)

  • Penny A New, BBA · 513-332-7931 · penny.new@cchmc.org
  • Carrie Stevens, BS · 513-636-9973 · carrie.stevens@cchmc.org
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Regional Phenotyping of CF and Non-CF Bronchiectasis (NCT04793867) | Bored Studies