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Rehab and Mechanical Ventilation

University of Florida · NCT07427121

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 25–80 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
16
US sites recruiting
1
Study start
March 30, 2026
Record last updated
May 5, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness. High levels of MV support have been reported to alter the function of the diaphragm muscle, the primary breathing muscle, in people with compromised health. However, rehabilitation may have some potential to improve diaphragm function in advance of using MV. This study will test different rehabilitation interventions, including (1) inspiratory strength training (IST), (2) transcutaneous spinal cord stimulation (TSCS), or sham TSCS. Before and after MV, participants will complete breathing strength tests and responses to phrenic nerve stimulation.

Being studied: Spinal cord stimulation; Inspiratory Strength Training; Sham Stimulation

Conditions: Inspiratory Strength Training (IST); Transcutaneous Spinal Stimulation; Sham Spinal Stimulation

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Non-smokers Sedentary or recreationally active Normal lung function No history of claustrophobia

Exclusion Criteria

Current smoking or vaping Obstructive lung disease Use of antibiotics or systemic corticosteroids to treat an acute condition History of sepsis or metastatic disease Post infectious conditions that affect breathing Diagnosed with a neurological or neuromuscular condition Any use of supplemental oxygen, continuous positive airway pressure (CPAP), or other positive pressure ventilation to treat sleep apnea Cardiac disease Orthopedic conditions that impair lung expansion Pregnancy Implanted metallic devices within 10 cm of the cervical spine

Recruiting US locations

  • University of Florida

    Gainesville, FL 32610

    Site contact: Barbara K. Smith, PhD · 352-294-5315 · bksmith@phhp.ufl.edu

Study contacts (from the official record)

  • Barbara K Smith, PhD, PT · 352-294-5315 · bksmith@ufl.edu
  • Ushna Khan, MD · 352-273-6855 · ushnakhan@ufl.edu
All healthy volunteers studies in Florida →
Rehab and Mechanical Ventilation (NCT07427121) | Bored Studies