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Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches

State University of New York - Upstate Medical University · NCT06112093

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–55 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
60
US sites recruiting
1
Study start
October 23, 2023
Record last updated
October 10, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI). rTMS has been shown to be effective in reducing chronic headaches without side effects commonly seen in medications, such as sleepiness and addiction. This study uses rTMS to manage chronic headaches to improve post-concussion symptoms and reduce the economic burden due to delayed recovery. This project aims to better identify biomarkers for diagnosis and prognosis and maximize recovery from mTBI.

Being studied: Repetitive Transcranial Magnetic Stimulation; Sham Repetitive Transcranial Magnetic Stimulation

Conditions: Brain Concussion; Mild Traumatic Brain Injury; Headache; Post-Concussion Symptoms

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 18 - 55 years old
  • mTBI with loss of consciousness for less than 30 min, initial Glasgow Coma Scale between 13 and 15, or post-traumatic amnesia for ≤ 24 hours
  • diagnosis of persistent post-traumatic headache according to the International Classification of Headache Disorders, 3rd edition (ICHD-3) criteria
  • headache develops within 7 days after head trauma
  • headache persists for >=3 months after head trauma despite receiving standard care
  • average persistent headache intensity is >= 3/10 of the numerical rating scale (NRS) on >=3days/week
  • no evidence of radiculopathy or peripheral neuropathy on electromyography or clinical evaluation
  • no evidence of other possible causes of headaches

Exclusion Criteria

  • history of chronic headache diagnoses such as migraine, tension, or cluster headaches prior to the incidence of mTBI
  • history of other neurologic conditions with medications affecting the central nervous system
  • contraindications of receiving TMS (e.g., a history of epileptic seizure and having implants like a cardiac pacemaker or intracerebral vascular clip

Recruiting US locations

  • SUNY Upstate Medical University

    Syracuse, NY 13210

    Site contact: Yi-Ling Kuo, PT, PhD · 3154646911 · kuoy@upstate.edu

Study contacts (from the official record)

  • Yi-Ling Kuo, PT, PhD · 3154646911 · kuoy@upstate.edu
All neurology studies in New York →
Repetitive Transcranial Magnetic Stimulation for Post-concussion… (NCT06112093) | Bored Studies