Repetitive Transcranial Magnetic Stimulation on Motor Function and Meta-Plasticity in Cerebral Palsy: TMS-EEG Study

Inclusion Criteria (CP):

• Aged 6 - 20 years,
• A confirmed diagnosis of CP by a specialized professional (pediatric neurologist, PM\&R physician, neonatal developmental specialist, or neonatologist) is a prerequisite for participation,
• Classified as high functioning (Level I, II, or III) according to the Gross Motor Function Classification System (GMFCS),
• Age-appropriate ability to understand and comply with study procedure throughout the entire duration of the study,
• Preserved vision and hearing (with or without correction).

Inclusion Criteria (TD):

• Aged 6 - 20 years
• Age-appropriate ability to understand and comply with study procedure throughout the entire duration of the study,
• Preserved vision and hearing (with or without correction).

Exclusion Criteria (CP):

• Syndromic or genetic brain-related associations,
• History of major trauma or brain surgery,
• Inability to remain still,
• History of Epilepsy,
• Severe coexisting sickness or illness unrelated to CP or unstable medical conditions such as pneumonia,
• Modified Ashworth Scale: Shoulder, elbow, and wrist scores more than 3,
• Limb contractures caused by any other injury except CP,
• Severe movement disorders that prevent intentional limb movements, such as choreoathetosis, or ballismus,
• Contraindications for rTMS include non-removable metallic objects close to a coil and implanted electronic devices, such as cochlear implants and pacemakers.

Exclusion Criteria (TD):

• Syndromic or genetic brain-related associations,
• History of major trauma or brain surgery,
• Inability to remain still,
• History of Epilepsy,
• Severe coexisting sickness or illness unrelated to CP or unstable medical conditions such as pneumonia,
• Limb contractures caused by injury,
• Severe movement disorders that prevent intentional limb movements, such as choreoathetosis, or ballismus,
• Contraindications for rTMS include non-removable metallic objects close to a coil and implanted electronic devices, such as cochlear implants and pacemakers.