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RecruitingAccepts healthy volunteersPhase 1/Phase 2

Retina is a Marker for Cerebrovascular Heath

Mayo Clinic · NCT04753970

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1, Phase 2
Target enrollment
100
US sites recruiting
1
Study start
February 9, 2021
Record last updated
August 3, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Cerebral small vessel disease (SVD), present in 80-94% of adults over age 65 years, increases the risk of stroke by 2-fold, and dementia by 2.3-fold. There is currently no treatment to slow SVD progression. This study aims to test whether impaired cerebral and retinal vasoreactivity may serve as biomarker for SVD progression, and to evaluate the safety and efficacy of cilostazol (antiplatelet agent with vasodilatory and anti-inflammatory properties) for the treatment of SVD.

Being studied: Cilostazol

Conditions: Cerebral Small Vessel Diseases; Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy; Cerebral Microbleeding; Sporadic White Matter Disease

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age ≥18 yo.
  • Diagnosis of CADASIL, sporadic WMD or lobar CMB and age-matched healthy controls (eg. patient's spouse or unrelated friends without SVD)

Exclusion Criteria

  • Age\<18yo
  • Pregnant
  • Breast feeding
  • Unable to follow commands
  • Unable to tolerate MRI

Recruiting US locations

  • Mayo Clinic Florida

    Jacksonville, FL 32224

    Site contact: Meredith McDonald · 904-953-4200 · mcdonald.meredith@mayo.edu

Study contacts (from the official record)

  • Meredith McDonald · 904-953-4200 · mcdonald.meredith@mayo.edu
All healthy volunteers studies in Florida →
Retina is a Marker for Cerebrovascular Heath (NCT04753970) | Bored Studies