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Role of Acetaldehyde in the Development of Oral Cancer

Masonic Cancer Center, University of Minnesota · with National Institutes of Health (NIH) · NCT05973656

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–45 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
170
US sites recruiting
1
Study start
July 8, 2022
Record last updated
July 22, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is a minimal risk intervention study where healthy volunteers and individuals with Fanconi anemia will consume a single dose of alcohol and provide primarily non-invasive biological samples at various time points. Biospecimens to be collected include saliva, oral cells collected via mouthwash and cheek brush, and urine. The collection of two blood samples (5 mL each) will be optional and banked for future use.

Being studied: Alcohol; Biospecimen Collection; Breath Test

Conditions: Alcohol-Related Carcinoma; Fanconi Anemia; Oral Cavity Carcinoma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 21-45 years of age for alcohol drinkers
  • Occasionally consume alcohol
  • At least 1 drink per month for healthy volunteers
  • At least 1 drink in the last 3 months for Fanconi anemia patients
  • Meets one of the three criteria
  • Healthy volunteer - ALDH2*1/1* homozygotes-not of Eastern Asian decent;
  • Healthy volunteer - ALDH2*1/2* heterozygotes-of Eastern Asian decent and experience flushing when drinking
  • Individual's with Fanconi anemia (FA).
  • 18-45 years of age for non-drinkers
  • Never consume alcohol/not had alcohol in the last 6 months
  • Healthy volunteers.
  • Non-smoker (smoked \< 100 cigarettes in a lifetime)

Exclusion Criteria

  • Pregnant or nursing
  • Taking any medication or drug that might affect alcohol use and absorption or that might be affected by alcohol consumption
  • Healthy volunteers who have taken any antibiotics in the last 3 months
  • Currently consuming more than 21 drinks per week
  • Have any history of alcohol or drug related problems
  • Current or former tobacco/nicotine product(s) user
  • Any regular use of tobacco/nicotine products or marijuana in the last year (cigarettes, e-cigarettes, cigars, pipes, smokeless tobacco)
  • "Trying" or limited use of any nicotine products or marijuana in the last 1 month
  • Active infection (influenza, cold, COVID, respiratory / sinus infection) - admission in the study will be delayed pending improved health
  • Non-FA volunteers who have an unstable medical condition or condition that could be affected by alcohol consumption (insulin-dependent diabetes, ulcers, heart issues)
  • Experience severe adverse events (nausea, blacking out) when consuming even low doses of alcohol

Recruiting US locations

  • Masonic Cancer Center, University of Minnesota

    Minneapolis, MN 55455

    Site contact: Balbo Silvia, PhD · 612-624-4240 · balbo006@umn.edu

Study contacts (from the official record)

  • Balbo Silvia, PhD · 612-624-4240 · balbo006@umn.edu
All healthy volunteers studies in Minnesota →
Role of Acetaldehyde in the Development of Oral Cancer (NCT05973656) | Bored Studies