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RecruitingAccepts healthy volunteersPhase 4

Role of Menopause in Thermoregulation

Penn State University · NCT06798571

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 42–64 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
24
US sites recruiting
1
Study start
March 1, 2025
Record last updated
October 2, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men.

Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.

Being studied: Elagolix Oral Tablet; Estradiol patch; cellulose placebo; placebo patch

Conditions: Menopause; Aging

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Women ages 42-64

Exclusion Criteria

  • Chron's disease, diverticulitis, or similar gastrointestinal disease
  • Abnormal resting exercise electrocardiogram (ECG)
  • Tobacco use
  • High-risk determined by the Atherosclerotic Cardiovascular Disease (CVD) Risk Factor
  • Assessment
  • Using hormone therapy
  • Using hormonal contraceptives

Recruiting US locations

  • Noll Laboratory

    University Park, PA 16802

    Site contact: W. Larry Kenney, Ph.D. · 814-863-1672 · w7k@psu.edu

Study contacts (from the official record)

  • W. Larry Kenney, Ph.D. · 814-863-1672 · w7k@psu.edu
  • Olivia K. Leach, MS · okl5046@psu.edu
All women’s health studies in Pennsylvania →
Role of Menopause in Thermoregulation (NCT06798571) | Bored Studies