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RecruitingAccepts healthy volunteersPhase 1

Safety of Anal Curcumin

Lisa Flowers · NCT06626230

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 30+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
48
US sites recruiting
2
Study start
March 17, 2025
Record last updated
August 18, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to see if curcumin can reverse anal high-grade squamous intraepithelial lesions (aHSIL) (high-grade anal precancerous cells or high-grade abnormal cells) in people living with HIV to avoid current treatments such as ablation (destroying abnormal cells with heat or surgical excision (cutting out the abnormal cells)), which have potential short- and long-term side effects.

Being studied: Curcuminoid Capsules

Conditions: Anal High Grade Squamous Intraepithelial Lesion

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Major Inclusion Criteria

  • 30 and older
  • Have biopsy-proven anal intraepithelial neoplasia (AIN) 2, AIN 3 without previous treatment
  • Or cytology results for ASC-H or HSIL
  • Able and willing to complete Study Diary
  • Other inclusion criteria apply

Exclusion Criteria

  • Have a clinically significant chronic medical condition that is considered progressive, such as but not limited to coronary disease, congestive heart failure, chronic obstructive lung disease, and diabetes mellitus. Chronic nonprogressive or intermittent syndromes are not excluded, including migraine headaches, mild reactive airway disease, controlled hypertension, stable pain syndromes, or benign gastric reflux.
  • Have any history of anal cancer malignancy.
  • Pregnant or planning to become pregnant in the next three months.
  • Have a history of sensitivity or allergy to any compound used in this study.
  • Have Grade 2 or higher renal or hematology abnormality,
  • Are currently using, or in the last year have used intravenous drugs (except for therapeutic use), recreational drugs, or alcohol abuse.
  • Other exclusion criteria apply

Recruiting US locations

  • Grady Memorial Hospital

    Atlanta, GA 30303

  • Grady Hospital - Ponce De Leon Clinic

    Atlanta, GA 30308

    Site contact: Lisa Flowers, MD

Study contacts (from the official record)

  • Lisa Flowers, MD, MPH · 404-251-8931 · lflowe2@emory.edu
All healthy volunteers studies in Georgia →
Safety of Anal Curcumin (NCT06626230) | Bored Studies