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RecruitingAccepts healthy volunteersEarly Phase 1

Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

University of Missouri-Columbia · NCT05219799

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–45 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
72
US sites recruiting
1
Study start
March 14, 2023
Record last updated
July 28, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.

Being studied: Propranolol Hydrochloride; Isoproterenol; Phentolamine Mesylate; Norepinephrine

Conditions: Obesity; Vasodilation; Healthy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • BMI >18 kg/m2

Exclusion Criteria

  • Pregnancy, breastfeeding
  • Diagnosed sleep apnea or AHI >10 events/hr
  • Current smoking/Nicotine use
  • Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
  • Nerve/neurologic disease
  • Cardiovascular, hepatic, renal, respiratory disease
  • Blood pressure ≥140/90 mmHg
  • Diabetes, Polycystic ovarian syndrome
  • Communication barriers
  • Prescription medications, Sensitivity to lidocaine

Recruiting US locations

  • University of Missouri

    Columbia, MO 65211

    Site contact: Jennifer L Harper · 5738822544 · harperjl@missouri.edu

Study contacts (from the official record)

  • Jacqueline K Limberg, Ph.D. · 5738822544 · limbergj@missouri.edu
All weight loss studies in Missouri →
Sex Disparities in Hypoxic Vasodilation and Impact of Obesity (NCT05219799) | Bored Studies