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RecruitingAccepts healthy volunteersPhase 1/Phase 2

Sleep Disordered Breathing With Opioid Use

VA Office of Research and Development · with John D. Dingell VA Medical Center · NCT05589753

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–89 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1, Phase 2
Target enrollment
150
US sites recruiting
1
Study start
May 2, 2019
Record last updated
July 1, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

There is an increased risk for sleep disordered breathing (SDB), sleep-related hypoventilation and irregular breathing in individuals on chronic prescription opioid medications. Almost 30% of a veteran sleep clinic population had opioid-associated central sleep apnea (CSA). The proposal aims to identity whether oxygen and acetazolamide can be effective in reducing unstable breathing and eliminating sleep apnea in chronic opioid use via different mechanisms. We will study additional clinical parameters like quality of life, sleep and pain in patients with and without opioid use. This proposal will enhance the investigators' understanding of the pathways that contribute to the development of sleep apnea with opioid use. The investigators expect that the results obtained from this study will positively impact the health of Veterans by identifying new treatment modalities for sleep apnea.

Being studied: Hyperoxia; Acetazolamide

Conditions: Sleep Apnea; Opioid Use; Sleep Disordered Breathing

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Veterans, age 18-89 years
  • Veterans with prescription opioids

Exclusion Criteria

  • Patients with BMI>40kg/m2 will be excluded to avoid the effects of morbid obesity on pulmonary mechanics and ventilatory control
  • Patients with history of unresolved/untreated cardiac disease, including recent myocardial infarction, recent bypass surgery, untreated atrial and ventricular tachy-bradycardias
  • Congestive heart failure with Cheyne-Stokes respiration (CSR)
  • Current unstable angina
  • Recent stroke
  • Untreated schizophrenia
  • Untreated hypothyroidism
  • Unresolved seizure disorder
  • Severe respiratory, neurological, liver and renal diseases
  • Unstable psychiatric disorders/untreated PTSD
  • Traumatic brain injury
  • Pregnant women
  • Significant sleep disorder such as narcolepsy, parasomnias disorder
  • Failure to give informed consent
  • Patients on tramadol and suboxone/buprenorphine

Recruiting US locations

  • John D. Dingell VA Medical Center, Detroit, MI

    Detroit, MI 48201-1916

    Site contact: Ruchi Rastogi, MS · (313) 576-4464 · ruchi.rastogi@va.gov

Study contacts (from the official record)

  • Ruchi Rastogi, MS · (313) 576-4464 · ruchi.rastogi@va.gov
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Sleep Disordered Breathing With Opioid Use (NCT05589753) | Bored Studies