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Slowly Digestible Carbohydrates for GLP-1 Secretion

Purdue University · NCT07572513

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–45 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
19
US sites recruiting
1
Study start
May 1, 2026
Record last updated
May 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trail is to learn if the hormone, glucagon-like peptide-1 (GLP-1), is stimulated by slowly digestible carbohydrates (SDCs) in healthy adults. In the current study, researchers will observe the amount of SDC that results in clinically meaningful levels of GLP-1, shown by an increase in feelings of fullness and a decrease in hunger, and how long an elevated level of GLP-1 lasts after starch consumption. Researchers aim to address two questions: What amount of SDC maximizes GLP-1-mediated satiety, and does the impact to satiety continue in a second meal? The overall goal is to maximize ileal-digesting SDC's potential use as a food-based agent for weight loss.

Researchers will compare 20, 40, and 60 g of raw corn starch compared to a maltodextrin control on total plasma GLP-1 concentrations, insulin, and blood glucose at baseline and 15, 30, 60, 90, 120, and 180 minutes post-consumption of SDC. Researchers will also measure satiety at baseline, 60, 120, 180 minutes and after a second meal.

There will be a total of 4 study visits with a least a 7-day break between visits. At each study visit, participants will:

  • Consume a randomized test beverage (SDC or maltodextrin)
  • Receive a blood draw at 7 timepoints over 3 hrs
  • Take a satiety questionnaire 5 times over 3 hrs
  • Consume a standardized lunch 3 hrs after the test beverage consumption

Being studied: Maltodextrin (Placebo); Raw Corn Starch

Conditions: Blood Glucose; GLP-1; Satiety; Second Meal Intake; Healthy Participant Study

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Healthy population
  • BMI between 18.5 and 24.9 kg/m2
  • Adults 18 - 45 years old
  • Men or women
  • Able to read/speak English
  • Fasting blood glucose levels ≤100 mg/dL
  • HbA1c ≤ 5.7%

Exclusion Criteria

  • Participants with 18 > Years of Age > 45 will be excluded.
  • Subjects with 18.5 kg/m² > BMI > 24.9 kg/m² will be excluded.
  • Diabetic individuals will be excluded.
  • Individuals with history of gastrointestinal disease will be excluded from the study.
  • Pregnant or nursing women will also be excluded.
  • Individuals taking GLP-1 medications, or on weight-loss diets or restrictive eating patterns.
  • Individuals suffering from dairy or gluten intolerance or allergies will be excluded.

Recruiting US locations

  • Clinical Research Center at Purdue University

    West Lafayette, IN 47907

    Site contact: Cheryl Armstrong, Ph.D. · 765-496-6275 · armstroc@purdue.edu

Study contacts (from the official record)

  • Bruce R Hamaker, Ph.D. · 765-494-5668 · hamakerb@purdue.edu
  • Erica de Jong, B.s. · 7654963802 · dejonge@purdue.edu
All nutrition & metabolism studies in Indiana →
Slowly Digestible Carbohydrates for GLP-1 Secretion (NCT07572513) | Bored Studies