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Stress and Pain in People Living With HIV

Yale University · with National Institute on Drug Abuse (NIDA) · NCT06784908

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–68 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
120
US sites recruiting
1
Study start
January 16, 2025
Record last updated
April 27, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is a basic human experimental study utilizing 4 groups of individuals with and without HIV and complex morbidities of cannabis use disorder and major depression who will participate in 2 sessions of the Yale Pain Stress Task (YPST) and follow-up phase to assess drug use and mood symptoms.

Being studied: Yale Pain Stress Task (YPST)

Conditions: HIV; Depression; Cannabis Use Disorder; Stress; Pain

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • good health as verified by screening examination
  • Able to read English and complete study evaluations and provide informed written and verbal consent. Additional criteria PLWH
  • HIV-1 lab test positive
  • undetectable viral load
  • good ART adherence

Additional criteria by group

PLWH +CM:

  • CB positive urine toxicology
  • meet DSM-5 criteria for CUD and MDD as assessed using SCID-I. HC
  • HIV-1 test negative
  • urine toxicology negative
  • no major medical and psychiatric diagnoses based on DSM-V.

PLWH Only

  • HIV-1 test positive
  • urine toxicology negative
  • no major medical and psychiatric diagnoses based on DSM-V.

CM Only

  • HIV-1 test negative
  • urine toxicology positive
  • meet DSM-5 criteria for CUD and MDD as assessed using SCID-I

Exclusion Criteria

  • meet primary, current moderate and severe criteria for other SUD including cocaine, alcohol, opiates, sedatives, nicotine
  • current use or past history of cocaine or opioid use disorder
  • history of any psychotic disorder
  • current diagnoses of bipolar disorder and PTSD
  • psychotic or otherwise severely psychiatrically disabled (i.e., suicidal, homicidal, current mania)
  • significant underlying medical conditions such as cerebral, renal, thyroid or cardiac pathology that would interfere with study participation
  • medications with known central effects on HPA axis and cytokines/immune function
  • women who are pregnant, nursing or those using hormonal birth control that affect HPA axis cortisol responses.

Recruiting US locations

Study contacts (from the official record)

  • Rachel Hart, MA · 203-737-4791 · Rachel.hart@yale.edu
All mental health studies in Connecticut →
Stress and Pain in People Living With HIV (NCT06784908) | Bored Studies