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Stress Phenotypes and Preterm Birth

Columbia University · with National Institute on Minority Health and Health Disparities (NIMHD) · NCT05229666

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
200
US sites recruiting
1
Study start
December 9, 2021
Record last updated
May 14, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Pregnancy ends in preterm birth (PTB) for approximately 1 in 10 women, though more often for Non-Hispanic Black women, 14.12% PTB rate, compared to 9.09% for Non-Hispanic White women. Psychosocial stress and childhood trauma each are associated with risk for PTB and PTB has an intergenerational impact: mothers born preterm are more likely to give birth preterm, especially amongst Black women. In this project, we will study mitochondria, which contain their own genome, the mitochondria DNA, and are inherited from the mother, as they represent a potential intersection point between psychosocial experiences and their biological embedding in underlying disease outcomes such as PTB

Being studied: Cognitive Challenge

Conditions: Preterm Birth; Inflammation; Stress; Mental Health Issue

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Pregnant women 18 years of age or older (based on self-report)
  • Not currently smoking, drinking alcohol, or taking drugs (based on self-report)
  • Planning to deliver at CUIMC/NYP (based on self-report)
  • In the first or second trimester of pregnancy (prior to 28 weeks gestation) (based on self-report of estimated date of delivery)

Exclusion Criteria

  • Multi-fetal pregnancy (based on self-report)
  • Taking medications regularly that affect the cardiovascular and inflammatory systems, including NSAIDS and other anti-inflammatories, α blockers, β blockers, corticosteroids, chronic-use asthma medications (e.g. beta2- adrenoceptor agonists) (based on self-report)
  • This does NOT include baby aspirin or low-dose aspirin, as baby aspirin / low-dose aspirin is not normally considered to be an NSAID.
  • Inflammatory conditions including rheumatoid arthritis, lupus, and multiple sclerosis (based on self-report)

Recruiting US locations

  • Columbia University Irving Medical Center

    New York, NY 10032

    Site contact: Catherine Monk, PhD · 917-543-6031 · cem31@columbia.edu

Study contacts (from the official record)

  • Catherine Monk, PhD · 646-774-8941 · cem31@cumc.columbia.edu
  • Elizabeth Werner, PhD · 646-774-8835 · ew150@cumc.columbia.edu
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Stress Phenotypes and Preterm Birth (NCT05229666) | Bored Studies