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StuDy AimED at Increasing AlCohol AbsTinEnce

University of Illinois at Chicago · with National Institute on Alcohol Abuse and Alcoholism (NIAAA) · NCT05778734

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–24 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
104
US sites recruiting
1
Study start
July 30, 2023
Record last updated
May 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to test the feasibility \& acceptability of an integrated CM-PST intervention (in K99 phase) and preliminary efficacy (in R00 phase), vs. CM alone, to improve treatment efficacy and inform about neural mechanisms of treatment effects in young adults with Alcohol Use Disorder (AUD).

The aims are as follows

K99 Aim: Test feasibility \& acceptability of a developed CM-PST, by meeting these benchmarks: 2a Feasibility: enroll 20 participants in the new CM-PST in a single-arm pre- and post-study, and retain ≥85% at wk 12. 2b Deliver CM-PST at ≥90% fidelity to intervention protocol. 2c Acceptability to participants: Achieve mean score ≥3 on Client Satisfaction Scale Questionnaire and satisfaction from semi-structured interviews.

R00 Aim 1) Test preliminary efficacy of CM-PST in a 2-arm pilot RCT: Male/female young adults (aged18-24) who meet AUD criteria will be randomized to CM-PST or CM-only control, and assessed at baseline (0), 3, and 6 months. Primary study endpoint will be 3 months.

R00 Aim 2 (Exploratory) Explore potential neural mechanisms of CM-PST effects, by fMRI scanning \& analyses of core regions of the brain circuits regulating positive affect (ventral striatum), negative affect (amygdala), and cognitive control (dorsolateral prefrontal cortex), and connectivity between these core regions.

Being studied: CM-PST; CM only

Conditions: Alcohol Use Disorder

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Male and female young adults aged 18-24 yr
  • English-speaking
  • Current alcohol use greater or equal to 1 day/week via phone screening, and meet criteria for (past year) mild, moderate or severe AUD on the AUDIT and AUDADIS surveys.
  • Completion of written informed consent
  • Baseline screening study visit.

Exclusion Criteria

  • Participation in past 6 mo. in AUD or substance use treatment
  • Current use of medications used to treat AUD (e.g., naltrexone)
  • Lifetime DSM-5 diagnosis of schizophrenia, bipolar disorder, or any psychotic disorder.
  • Current use of psychoactive drugs, determined by positive drug toxicology screen
  • Conditions (e.g., tic disorder) that would interfere with psychophysiological indices of reward functioning
  • Pregnancy or intention to become pregnant
  • Additional exclusion criteria pertaining to fMRI scan in R00 phase only: a) bodily ferrous metals (e.g., aneurysm clips, shrapnel/retained particles) or b) claustrophobia, inability to tolerate small enclosed spaces.

Recruiting US locations

  • University of Illinois at Chicago

    Chicago, IL 60608

    Site contact: Hagar Hallihan

Study contacts (from the official record)

  • Hagar Hallihan, PhD · 312-413-5361 · hhalli2@uic.edu
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StuDy AimED at Increasing AlCohol AbsTinEnce (NCT05778734) | Bored Studies