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RecruitingAccepts healthy volunteersPhase 3

Switching to E-cigarettes in Smokers Not Interested in Quitting

University of Kansas Medical Center · NCT05703672

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 3
Target enrollment
500
US sites recruiting
2
Study start
July 17, 2023
Record last updated
October 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The objectives of this application are to 1) compare short- and long-term harm reduction and abuse liability potential of a nicotine salt pod-based electronic cigarettes (EC) in adult (AA) exclusive EC, dual cig-EC, and exclusive cig users, 2) characterize factors that predict who switches fully, partially, or not at all, and 3) examine if harm reduction can be further enhanced by treating dual users with varenicline (VAR) to eliminate cigarette smoking.

Being studied: Varenicline Tartrate; Placebo; Electronic cigarette

Conditions: Smoking Reduction

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • ≥ 21 years of age
  • Smoke >5 cigarettes per day
  • Smoked cigarettes for > 6 months
  • Verified smoker (CO > 5 ppm)
  • Functioning telephone
  • Interested in switching to EC
  • Willing to take varenicline and complete all study visits

Exclusion Criteria

  • Interested in quitting smoking
  • Use of smoking cessation pharmacotherapy in the month prior to enrollment
  • Use of other tobacco products in past 30 days (i.e., cigarillos, cigars, hookah, smokeless tobacco, pipes)
  • EC use on > 4 of the past 30 days
  • Uncontrolled hypertension: BP > 180 (systolic) or > 105 (diastolic)
  • Heart-related event in the past 30 days
  • Medical contraindications to VAR: unstable cardiac condition (e.g., unstable angina or AMI) cardiac event, or stroke in the past 4 weeks; renal impairment; history of clinically significant allergic reactions; history of epilepsy or seizure disorder; hospitalized for psychiatric issue in past 30 days; active suicidal ideation
  • Pregnant, contemplating getting pregnant, or breastfeeding
  • Plans to move from Kansas City metro area during the treatment and follow-up phase
  • Another household member enrolled in the study

Recruiting US locations

  • Swope Health Central

    Kansas City, MO 64130

    Site contact: Tricia Snow · 816-599-5311 · psnow@kumc.edu

  • University of Kansas Medical Center

    Kansas City, MO 64130

    Site contact: Tricia Snow, MPH · 816-398-8960 · psnow@kumc.edu

Study contacts (from the official record)

  • Tricia Snow, MPH · 816-398-8960 · psnow@kumc.edu
All smoking & vaping studies in Missouri →
Switching to E-cigarettes in Smokers Not Interested in Quitting (NCT05703672) | Bored Studies