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Sympatholysis in Chronic Kidney Disease

Emory University · NCT02411773

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–75 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
110
US sites recruiting
1
Study start
June 11, 2015
Record last updated
May 18, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate).

Being studied: Sodium Bicarbonate; Placebo; Exercise Training; Control to Exercise (Stretching)

Conditions: Chronic Kidney Disease

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Veterans with Stages III and IV Chronic Kidney Disease (CKD)
  • Kidney transplant recipients with varying degrees of kidney function
  • Veterans 18-75 years old, without kidney disease, as study controls
  • Exercise less than 20 minutes twice per week
  • Willing and able to cooperate with the protocol

Exclusion Criteria

  • Severe CKD (estimated glomerular filtration rate (eGFR) \< 15 cc/minute)
  • Metabolic alkalosis (serum bicarbonate > 28 meq/L)
  • Ongoing drug or alcohol abuse
  • Diabetic neuropathy
  • Any serious systemic disease that might influence survival
  • Severe anemia with hemoglobin (Hbg) level \< 10 g/dL
  • Clinical evidence of congestive heart failure or ejection fraction below 35%
  • Symptomatic heart disease determined by prior electrocardiogram, stress test, and/or history
  • Treatment with central alpha agonists (clonidine)
  • Uncontrolled hypertension with blood pressure (BP) greater than 170/100 mmHg
  • Low blood pressure with BP less than 100/50 mmHg
  • Pregnancy or plans to become pregnant
  • Current treatment with monoamine oxidase inhibitors (MAOIs)
  • Inability to exercise on a stationary bicycle

Recruiting US locations

  • Atlanta VA Medical Center

    Decatur, GA 30033

    Site contact: Dana DaCosta · 404-727-7762 · drdacos@emory.edu

Study contacts (from the official record)

  • Dana DaCosta · 404-727-7762 · drdacos@emory.edu
  • Jeanie Park, MD · 404-321-6111
All healthy volunteers studies in Georgia →
Sympatholysis in Chronic Kidney Disease (NCT02411773) | Bored Studies